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dc.contributor.authorJana, P-
dc.contributor.authorKoppayithodi, S-
dc.contributor.authorMurali, M-
dc.contributor.authorSaha, M-
dc.contributor.authorMaiti, K K-
dc.contributor.authorBandyopadhyay, S-
dc.date.accessioned2023-10-10T08:57:36Z-
dc.date.available2023-10-10T08:57:36Z-
dc.date.issued2023-04-11-
dc.identifier.citationACS Sensors; 8(4):1693-1699en_US
dc.identifier.urihttps://pubs.acs.org/doi/full/10.1021/acssensors.2c02849-
dc.identifier.urihttp://localhost:8080/xmlui/handle/123456789/4542-
dc.description.abstractSialic acid (SA) is an acidic monosaccharide present in the human brain and body fluids in the form of N-acetylneuraminic acid. It is also a well-known cancer biomarker. For decades, it has remained a challenging task to design synthetic receptors for SA. However, mainly because of the interference from other sugars with the receptors, it was challenging to differentiate SA from other sugars. Here, we report the development of a two-component aggregation-induced emissive (AIE) probes that can interact with SA and other saccharides via noncovalent interactions with unique emission fingerprints. Analysis of the output signals enabled the reliable detection and clear discrimination of SA in the presence of other saccharides with high accuracy. Further, its potential application in cellular glycan mapping has been explored by fluorescence imaging and surface-enhanced Raman scattering with MDA-MB-231 breast cancer cells.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectsialic aciden_US
dc.subjectAIEgensen_US
dc.subjectnoncovalent interactionsen_US
dc.subjectmultivariate analysisen_US
dc.subjectfluorescenceen_US
dc.subjectSERSen_US
dc.titleDetection of Sialic Acid and Imaging of Cell-Surface Glycan Using a Fluorescence–SERS Dual Probeen_US
dc.typeArticleen_US
Appears in Collections:2023

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