Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/4725
Title: Engineering semi-permeable giant liposomes
Authors: Radhakrishnan, S
Nair, K S
Nandi, S
Bajaj, H
Issue Date: 31-Oct-2023
Publisher: Royal Society of Chemistry
Citation: Chemical Communications; 59(93):13863-13866
Abstract: Giant unilamellar vesicles (GUVs) with a semi-permeable nature are prerequisites for constructing synthetic cells. Here we engineer semi-permeable GUVs by the inclusion of DOTAP lipid in vesicles. Diffusion of molecules of different charge and size across GUVs are reported. Control over size-selective permeability is demonstrated by modulating the DOTAP lipid composition in different lipid systems without reconstituting membrane proteins. Such semi-permeable GUVs have immense applications for constructing synthetic cells.
URI: https://pubs.rsc.org/en/content/articlelanding/2023/CC/D3CC04039A
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