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dc.contributor.authorAjesh P Thomas-
dc.contributor.authorSaneesh Babu, P S-
dc.contributor.authorAsha Nair, S-
dc.contributor.authorRamakrishnan, S-
dc.contributor.authorRamaiah, D-
dc.contributor.authorChandrashekar, T K-
dc.contributor.authorSrinivasan, A-
dc.contributor.authorRadhakrishna Pillai, M-
dc.date.accessioned2013-06-17T11:08:10Z-
dc.date.available2013-06-17T11:08:10Z-
dc.date.issued2012-06-14-
dc.identifier.citationJournal of Medicinal Chemistry 55(11):5110-5120;14 Jun 2012en_US
dc.identifier.urihttp://hdl.handle.net/123456789/477-
dc.description.abstractA water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC50 values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS)generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniquesen_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectN-confused porphyrinen_US
dc.subjectPhotodynamic therapyen_US
dc.subjectPhotosensitizeren_US
dc.subjectSinglet oxygen generationen_US
dc.subjectCore-modified porphyrinsen_US
dc.subjectPhotophysical propertiesen_US
dc.subjectInduced apoptosisen_US
dc.titleMeso-tetrakis(p-sulfonatophenyl)N-confused porphyrin tetrasodium salt: a potential sensitizer for photodynamic therapyen_US
dc.typeArticleen_US
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