An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides

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Title:	An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides
Authors:	Nayana Joseph Rani Rajan Jubi John Devika, N V Sarath Chand, S Suresh, E Pihko, P M Radhakrishnan, K V
Keywords:	Meso bicyclic hydrazines Facile synthesis Enantioselective desymmetrization Functionalized cyclopentenes Stereoselective-synthesis Glycosidase inhibitors Diazabicyclic alkenes Tertiary-amines Reagents Cyclopentannulation
Issue Date:	2013
Publisher:	Royal Society of Chemistry
Citation:	RSC Advances 3(21):7751-7757;2013
Abstract:	A simple and efficient method for the stereoselective ring opening of bicyclic hydrazines with various aryl halides under palladium catalysis has been elaborated. The reactions afforded trans-3,4-disubstituted cyclopentenes or alkylidene cyclopentenes in good to excellent yields. By taking advantage of multiple points of functionalization in the synthesized trans-3-phenyl-4-hydrazino-cyclopentene, we have synthesized the antidepressant Cypenamine (trans-2-phenylcyclopentylamine).
URI:	http://hdl.handle.net/123456789/632
Appears in Collections:	2013

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