Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/645
Title: Emerging approaches in fermentative production of statins
Authors: Singh, S K
Pandey, A
Keywords: Statins
Agro-industrial residues
Submerged fermentation
Solid-state fermentation
Issue Date: 2013
Publisher: Springer
Citation: Applied Biochemistry and Biotechnology 171(4):927-938;Oct 2013
Abstract: Microbial metabolites have many important applications in pharmaceutical and health-care industry. The products of microbial origin are usually produced by submerged fermentation. The solid-state fermentation represents an alternative mode of fermentation, which is increasingly being employed as an alternative to submerged fermentation for metabolite production. The prospect of producing high-value product using low-value raw material offers a substantial premium to switch to these technologies. The cost of statins being one major factor, solid-state fermentation with agro-industrial residues as carbon, nitrogen and support matrix, promises to substantially lower the cost of production. Hence, newer approaches are required to exploit the agro-industrial residues for statin production. The development of these technologies offers an opportunity to exploit low-cost substrates without substantial investment in newer production methodologies. The emerging evidence of beneficial effect of statins in applications other than lipid lowering such as in Alzheimer disease, HIV, age-related dementia, and cancer chemotherapy makes it very important to develop methods for economic production of statins.
URI: http://hdl.handle.net/123456789/645
Appears in Collections:2013

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