Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro

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Title:	Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro
Authors:	Divya, L Werngren, J Jose, L Suja, K P Mangalam S Nair Luxmi Varma, R Sathish, M Hoffner, S Kumar, R A
Keywords:	Antimycobacterial M. tuberculosis K. galangal REMA Ethyl p-methoxycinnamate
Issue Date:	2011
Publisher:	Elsevier
Citation:	Fitoterapia 82(5):757-761;Jul 2011
Abstract:	Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA). EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485 mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule.
URI:	http://ir.niist.res.in:8080/jspui/handle/123456789/739
ISSN:	0367-326X
Appears in Collections:	2011

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