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Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/739
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dc.contributor.authorDivya, L-
dc.contributor.authorWerngren, J-
dc.contributor.authorJose, L-
dc.contributor.authorSuja, K P-
dc.contributor.authorMangalam S Nair-
dc.contributor.authorLuxmi Varma, R-
dc.contributor.authorSathish, M-
dc.contributor.authorHoffner, S-
dc.contributor.authorKumar, R A-
dc.date.accessioned2013-11-13T08:05:53Z-
dc.date.available2013-11-13T08:05:53Z-
dc.date.issued2011-
dc.identifier.citationFitoterapia 82(5):757-761;Jul 2011en_US
dc.identifier.issn0367-326X-
dc.identifier.urihttp://ir.niist.res.in:8080/jspui/handle/123456789/739-
dc.description.abstractMany plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA). EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485 mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectAntimycobacterialen_US
dc.subjectM. tuberculosisen_US
dc.subjectK. galangalen_US
dc.subjectREMAen_US
dc.subjectEthyl p-methoxycinnamateen_US
dc.titleEthyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitroen_US
dc.typeArticleen_US
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