Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/786
Title: Invitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers
Authors: Prathapan, A
Cherian, O L
Nampoothiri, S V
Mini, S
Raghu, K G
Keywords: HPLC
Phenolics
Ellagic acid
Lipid peroxidation
Xanthine oxidase
Ntioxidant activity
Flavonoids
Autoxidation
Metabolism
Mechanisms
Disease
Issue Date: 2011
Publisher: Taylor & Francis
Citation: Natural Product Research 25(3):298-309;2011
Abstract: Saraca ashoka is a widely used medicinal herb claimed to cure many diseases. This study investigated the antiperoxidative, free radical scavenging and xanthine oxidase (XO) inhibitory potential of the ethyl acetate fraction of S. ashoka flowers (SAF) and compared it with standard compounds like gallic acid, ascorbic acid, butylated hydroxyl toluene and allopurinol. The ethyl acetate fraction of SAF exhibited free radical scavenging activity against the 1,1-diphenyl-2-picrylhydrazyl radical and superoxide radical, along with hydroxyl radical scavenging activity. Lipid peroxidation inhibitory potential of SAF was studied using a linoleic acid emulsion system, which shows significant antioxidant potential. SAF also demonstrated significant XO (key enzyme linked to inflammation) inhibitory activity, which revealed its therapeutic potential as an antioxidant and XO inhibitor. HPLC profiling of the ethyl acetate fraction of SAF revealed that it contains ellagic acid as a major compound and thus the beneficial effects of this fraction may be due to the presence of this compound.
URI: http://ir.niist.res.in:8080/jspui/handle/123456789/786
ISSN: 1478-6419
Appears in Collections:2011

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