Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/842
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dc.contributor.authorVibin, M-
dc.contributor.authorVinayakan, R-
dc.contributor.authorAnnie John-
dc.contributor.authorRaji, V-
dc.contributor.authorRejiya, C S-
dc.contributor.authorVinesh, N S-
dc.contributor.authorAnnie Abraham-
dc.date.accessioned2013-11-26T09:35:30Z-
dc.date.available2013-11-26T09:35:30Z-
dc.date.issued2011-
dc.identifier.citationJournal of Nanoparticle Research 13(6):2587-2596;Jun 2011en_US
dc.identifier.issn1388-0764-
dc.identifier.urihttp://ir.niist.res.in:8080/jspui/handle/123456789/842-
dc.description.abstractThe toxicological effects of silica-coated CdSe quantum dots (QDs) were investigated systematically on human cervical cancer cell line. Trioctylphosphine oxide capped CdSe QDs were synthesized and rendered water soluble by overcoating with silica, using aminopropyl silane as silica precursor. The cytotoxicity studies were conducted by exposing cells to freshly synthesized QDs as a function of time (0-72 h) and concentration up to micromolar level by Lactate dehydrogenase assay, MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] assay, Neutral red cell viability assay, Trypan blue dye exclusion method and morphological examination of cells using phase contrast microscope. The in vitro analysis results showed that the silica-coated CdSe QDs were nontoxic even at higher loadings. Subsequently the in vivo fluorescence was also demonstrated by intravenous administration of the QDs in Swiss albino mice. The fluorescence images in the cryosections of tissues depicted strong luminescence property of silica-coated QDs under biological conditions. These results confirmed the role of these luminescent materials in biological labeling and imaging applications.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectCytotoxicityen_US
dc.subjectQuantum dotsen_US
dc.subjectSemiconductorsen_US
dc.subjectLuminescenceen_US
dc.subjectHealth safetyen_US
dc.subjectSilica-coatingen_US
dc.subjectEHSen_US
dc.subjectSurface modificationen_US
dc.subjectNanoparticlesen_US
dc.subjectToxicityen_US
dc.subjectSemiconductoren_US
dc.titleCytotoxicity and fluorescence studies of silica-coated CdSe quantum dots for bioimaging applicationsen_US
dc.typeArticleen_US
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