Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode

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Title:	Isolation and antifungal properties of cyclo(D-Tyr-L-Leu) diketopiperazine isolated from Bacillus sp. associated with rhabditid entomopathogenic nematode
Authors:	Nishanth Kumar Gorantla, J N Mohandas, C Bala Nambisan Ravi S Lankalapalli
Keywords:	Diketopiperazine Antifungal activity Minimum inhibitory concentration Disc diffusion method
Issue Date:	2013
Publisher:	Taylor & Francis
Citation:	Natural Product Research 27(23):2168–2172;2013
Abstract:	Bacillus sp. associated with an entomopathogenic nematode is shown to produce diketopiperazine (DKP) that showed stronger antifungal activity against Colletotrichum gloeosporioides [minimum inhibitory concentration (MIC): 8mgmL21] than commercial fungicide oligochitosan (MIC: 125 mgmL21). DKP identified as cyclo(DTyr- L-Leu) was isolated for the first time from a natural source with a D-tyrosine residue. This report also demonstrates for the first time an antifungal property exploration of cyclo(Tyr-Leu) class of dipeptides. The structural elucidation was carried out using 1D, 2D NMR methods and HPLC.
URI:	http://ir.niist.res.in:8080/jspui/handle/123456789/963
ISSN:	1478-6419
Appears in Collections:	2013

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