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Browsing by Author "Arun, K B"

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Acetylation of Isoniazid Is a Novel Mechanism of Isoniazid Resistance in Mycobacterium tuberculosis

Arun, K B; Madhavan, A; Abraham, B; Balaji, M; Sivakumar, K C; Nisha, P; Ajay Kumar, R (American Society for Microbiology, 2020-12-16)

Isoniazid (INH), one of the first-line drugs used for the treatment of tuberculosis, is a prodrug which is activated by the intracellular KatG enzyme of Mycobacterium tuberculosis The activated drug hinders cell wall ...
Anticancer Activity Studies of Cubebin Isolated From Piper Cubeba and its Synthetic Derivatives

Dhanya, S R; Farha, A K; Arya, R M; Arun, K B; Remani, P; Nisha, P; Sunil, V; Mangalam, S N (Elsevier, 2016-04-01)

(−)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer ...
A Comparative Evaluation of Antioxidant and Antidiabetic Potential of Peel from Young and Matured Potato

Arun, K B; Chandran, J; Dhanya, R; Krishna, P; Jayamurthy, P; Nisha, P (Elsevier, 2015-03)

In the present study antioxidant and antidiabetic potentials of potato peels at two different stages of maturity were evaluated and compared. Peels of young and mature potatoes (YP and MP) were sequentially extracted ...
Customized Yeast Cell Factories for Biopharmaceuticals: From Cell Engineering to Process Scale Up

Madhavan, A; Arun, K B; Sindhu, R; Krishnamoorthy, J; Reshmy, R; Sirohi, R; Pugazhendi, A; Awasthi, M K; Szakacs, G; Binod, P (Springer nature, 2021-12)

The manufacture of recombinant therapeutics is a fastest-developing section of therapeutic pharmaceuticals and presently plays a significant role in disease management. Yeasts are established eukaryotic host for heterologous ...
Design of Novel Enzyme Biocatalysts for Industrial Bioprocess: Harnessing the Power of Protein Engineering, High Throughput Screening and Synthetic Biology

Madhavan, A; Arun, K B; Binod, P; Sirohi, R; Tarafdar, A; Reshmy, R; Awasthi, M K; Sindhu, R (Elsevier, 2021-04)

Biocatalysts have wider applications in various industries. Biocatalysts are generating bigger attention among researchers due to their unique catalytic properties like activity, specificity and stability. However the ...
Editorial: Emerging perspectives on probiotics, prebiotics, and synbiotics for prevention and management of chronic disease

Arun, K B; Nisha, P; Finamore, A (Frontiers, 2023-10-26)

The human gastrointestinal system is a complex ecosystem housing approximately 1014 microorganisms crucial for gut health and immune function (1). These microorganisms produce metabolites able to influence several body ...
Engineering Interventions in Industrial Filamentous Fungal Cell Factories for Biomass Valorization.

Madhavan, A; Arun, K B; Sindhu, R; Jose, A A; Pugazhendhi, A; Binod, P; Sirohi, R; Reshmy, R; Awasthi, M K (Elsevier, 2022-01)

Filamentous fungi possess versatile capabilities for synthesizing a variety of valuable bio compounds, including enzymes, organic acids and small molecule secondary metabolites. The advancements of genetic and metabolic ...
Filamentous fungi for pharmaceutical compounds degradation in the environment: A sustainable approach

Arun, K B; Madhavan, A; Tarafdar, A; Sirohi, R; Anoopkumar, A N; Kuriakose, L L; Awasthi, M K; Binod, P; Varjani, S; Sindhu, R (Elsevier, 2023-08)

Pharmaceutical compounds play an important role in enhancing the quality of human life. They substantially increase the life expectancy of humans and the well-being of livestock. The expansion in the global human population ...
Metabolic Circuits and Gene Regulators in Polyhydroxyalkanoate Producing Organisms: Intervention Strategies for Enhanced Production

Sindhu, R; Madhavan, A; Arun, K B; Pugazhendhi, A; Reshmy, R; Awasthi, MK; Sirohi, R; Tarafdar, A; Pandey, A; Binod, P (Elsevier, 2021-05)

Worldwide worries upsurge concerning environmental pollutions triggered by the accumulation of plastic wastes. Biopolymers are promising candidates for resolving these difficulties by replacing non-biodegradable plastics. ...
Microbial production of nutraceuticals: Metabolic engineering interventions in phenolic compounds, poly unsaturated fatty acids and carotenoids synthesis

Madhavan, A; Arun, K B; Alex, D; Anoopkumar, A N; Emmanual, S; Chaturvedi, P; Varjani, S; Tiwari, A; Kumar, V; Reshmy, R; Awasthi, M K; Binod, P; Aneesh, E M; Sindhu, R (Springer, 2023)

Nutraceuticals have attained substantial attention due to their health-boosting or disease-prevention characteristics. Growing awareness about the potential of nutraceuticals for the prevention and management of diseases ...
Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect

Thomas, S; Arun, K B; Syama, H P; Reshmitha, T R; Nisha, P (Frontiers Media, 2017-09-12)

The study under investigation focuses on in vitro antiproliferative efficacy of the flavonoid morin and the mechanisms by which it inhibits the growth of colon cancer using SW480 colon cancer cells with emphasis on Warburg ...
Murraya koenigii extract blended nanocellulose-polyethylene glycol thin films for the sustainable synthesis of antibacterial food packaging

Aravind, M; Reshmy, R; Arun, K B; Eapen, P; Raveendran, S; Bipin G., N; Mukesh Kumar, A; Ashok, P; Parameswaran, B (Elsevier, 2023-02-22)

Non-biodegradable plastics are a worldwide problem that have a negative impact on all living things, including humans. Nanocellulose, an excellent biopolymer is known for their increasing uses in food, healthcare, cosmetics, ...
Musa Paradisiaca Inflorescence Induces Human Colon Cancer Cell Death by Modulating Cascades of Transcriptional Events

Arun, K B; Madhavan, A; Reshmitha, T R; Thomas, S; Nisha, P (Royal Society of Chemistry, 2018-01)

Colorectal cancer (CRC) is one of the leading causes of cancer death, and diet plays an important role in the etiology of CRC. Traditional medical practitioners in many South Asian countries use plantain inflorescence to ...
Nanobiocatalysts: Advancements and Applications in Enzyme Technology

Reshmy, R; Philip, E; Sirohi, R; Tarafdar, A; Arun, K B; Madhavan, A; Binod, P; Awasthi, M K; Varjani, S; Szakacs, G; Sindhu, R (Elsevier, 2021-10)

Nanobiocatalysts are one of the most promising biomaterials produced by synergistically integrating advanced biotechnology and nanotechnology. These have a lot of potential to improve enzyme stability, function, efficiency ...
Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

Arun, K B; Aswathi, U; Venugopal, V V; Madhavankutty, T S; Nisha, P (spinger, 2016-10-26)

Abstract Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). ...
Plantain peel - a potential source of antioxidant dietary fibre for developing functional cookies

Arun, K B; Persia, F; Aswathy, P S; Janu, C; Sajeev, M S; Jayamurthy, P; Nisha, P (Springer, 2015-10)

Plantain cultivar Nendran is popular as a staple food in many parts of India and deep fried chips made from raw matured Nendran are one of the popular snack items in India. This study aims to utilize peel from Nendran ...
Preconditioning L6 muscle cells with Naringin ameliorates oxidative stress and increases glucose uptake

Dhanya, R; Arun, K B; Nisha, V M; Syama, H P; Nisha, P; Santhosh Kumar, T R; Jayamurthy, P (PLOS, 2015-07-06)

Enhanced oxidative stress contributes to pathological changes in diabetes and its complications. Thus, strategies to reduce oxidative stress may alleviate these pathogenic processes. Herein, we have investigated Naringin ...
Probiotics and Gut Microbiome − Prospects and Challenges in Remediating Heavy Metal Toxicity

Arun, K B; Madhavan, A; Sindhu, R; Emmanual, S; Binod, P; Pugazhendhi, A; Sirohi, R; Reshmy, R; Awasthi, M K; Gnansounou, E; Pandey, A (Elsevier, 2021)

The gut microbiome, often referred to as “super organ”, comprises up to a hundred trillion microorganisms, and the species diversity may vary from person to person. They perform a decisive role in diverse biological functions ...
Promising Eco-friendly Biomaterials for Future Biomedicine: Cleaner Production and Applications of Nanocellulose

Reshmy, R; Philip, E; Madhavan, A; Arun, K B; Binod, P; Pugazhendhi, A; Awasthi, M K; Gnansounou, E; Pandey, A; Sindhu, R (Elsevier, 2021)

Cellulose nanomaterials are developing nowadays as a promising environmental friendlier biomaterial that can be extracted from native plant sources. These materials, because of their excellent physico-chemical and biological ...
Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide

Dhanya, R; Arun, K B; Syama, H P; Nisha, P; Sundaresan, A; Santhosh Kumar, T R; Jayamurthy, P (Elsevier, 2014)

Scientific evidence suggests a strong link between the oxidative stress-induced pathways and onset of diabetes and its complications. The present study evaluates the antidiabetic potential of the flavonoids, rutin and its ...

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