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Browsing by Author "Dhanya, B P"

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Accessing Polycyclic Terpenoids from Zerumbone via Lewis Acid Catalyzed Synthetic Strategies

Sharathna, P; Meenu, M T; Radhakrishnan, K V; Dhanya, B P; Gopalan, G; Sasikumar, P; Krishnan, R S; Kokkuvayil, V R (Thieme, 2020-07)

We herein disclose an effective strategy for the synthesis of [5.3.0] and [6.3.0] fused polycyclic terpenoids, which are important structural elements of natural products and biologically active compounds. The method ...
Comparison of Antidiabetic Potential of (+) and (-)-hopeaphenol, a Pair of Enantiomers Isolated from Ampelocissus indica (L.) and Vateria Indica Linn., with Respect to Inhibition of Digestive Enzymes and Induction of Glucose Uptake in L6 Myotubes

Sasikumar, P; Prabha, B; Reshmitha, T R; Veluthoor, S; Pradeep, A K; Rohit, K R; Dhanya, B P; Sivan, V V; Jithin, M M; Kumar, N A; Shibi, I G; Nisha, P; Radhakrishnan, K V (Royal society of chemistry, 2016)

The remarkable α-glucosidase inhibition exhibited by the acetone extract of the rhizome of Ampelocissus indica (L.) and stem bark of Vateria indica Linn. (IC50 23.2 and 1.47 μg mL−1) encouraged us to isolate the phytochemicals ...
Lewis-Acid-Catalyzed Activation of Zerumbone towards Sesquiterpenoid Derivatives: Sustainable Utilization of Abundant Natural Resources for the Synthesis of Chemically Diverse Architectures

Dhanya, B P; Greeshma, G; Sasikumar, P; Neethu, S; Meenu, M T; Sharathna, P; Jubi, John; Sunil, Varughese; Sabu, M; Dan, M; Radhakrishnan, K V (Wiley, 2018-01-08)

A facile Lewis-acid-catalyzed method for the synthesis of structurally diverse sesquiterpenoid derivatives from readily available and abundant 11-membered natural product zerumbone has been developed. Starting from ...
Metal-Free Trans-Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone

Greeshma, G; Dhanya, B P; Saranya, J; Reshmitha, T R; Baiju, T V; Meenu, M T; Mangalam S Nair; Nisha, P; Radhakrishnan, K V (Wiley, 2017-06-08)

Herein, we describe a metal-free, iodosobenzene diacetate mediated trans-aziridination of zerumbone by the direct use of sulfonamides. Preliminary in vitro screening showed that the synthesized compounds had better ...
Palladium/Lewis acid mediated domino reaction of pentafulvene derived diazabicyclic olefins: efficient access to spiropentacyclic motif with an indoline and pyrazolidine fused to cyclopentene

Sarath Chand, S; Jijy, E; Praveen, P; Szymoniak, J; Preethanuj, P; Dhanya, B P; Radhakrishnan, K V (American Chemical Society, 2013)

A palladium/Lewis acid mediated stepwise and one-pot transformation of pentafulvene derived diazabicyclic olefins is described. The reaction offers a facile strategy for the synthesis of novel spiropentacyclic motifs with ...
Studies on alpha-glucosidase, aldose reductase and glycation inhibitory properties of sesquiterpenes and flavonoids of Zingiber zerumbet Smith

Ajish, K R; Antu, K A; Riya, M P; Preetharani, M R; Raghu, K G; Dhanya, B P; Radhakrishnan, K V (Taylor & Francis, 2015)

Eight known phytochemicals, four sesquiterpenes and four flavonoids of Zingiber zerumbet were screened against alpha-glucosidase enzyme, aldose reductase enzyme and antiglycation property under in vitro conditions. The ...
Synthesis and In Vitro Evaluation of Zerumbone Pendant Derivatives: Potent Candidates for Anti-Diabetic and Anti-Proliferative Activities

Dhanya, B P; Greeshma, G; Reshmitha, T R; Saranya, J; Sharathna, P; Shibi, I G; Nisha, P; Radhakrishnan, K V (Royal Society of Chemistry, 2017-05-26)

A series of zerumbone pendant derivatives were synthesized and evaluated for their a-glucosidase, a-amylase and glycation inhibition activities. In our study, some of the derivatives showed potent inhibitory activity in ...
Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of alpha-glucosidase inhibitors

Ajish, K R; Dhanya, B P; Nayana Joseph; Priya Rani, M; Raghu, K G; Vineetha, V P; Radhakrishnan, K V (Elsevier Science, 2014)

A new strategy for the synthesis of novel zerumbone derivatives via a regioselective palladium catalyzed decarboxylative coupling reaction using arene carboxylic acids is described. The current methodology involves the ...
Synthetic Modifications of Zerum Bone and Their Biological Evaluation

Dhanya, B P (Chemical Sciences and Technology Division, National Institute for Interdisciplinary Science and Technology(CSIR), Thiruvananthapuram, 2018-03)
Trapping the Lewis acid generated transient species from pentafulvene derived diazanorbornenes with ortho-functionalized aryl iodides and aliphatic alcohols

Sarath Chand, S; Saranya, S; Preethanuj, P; Dhanya, B P; Jijy, E; Praveen, P; Sasidhar, B S; Szymoniak, J; Santhini, P V; Radhakrishnan, K V (Royal Society of Chemistry, 2014)

Herein we describe our efforts on the Lewis acid catalyzed stereoselective ring-opening of pentafulvene derived diazabicyclic olefins using various ortho-functionalized aryl iodides such as 2-iodoanilines, 2-iodophenols ...
Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells

Thomas, S; Dhanya, B P; Arun, K B; Sini, S; Dan, M; Radhakrishnan, K V; Nisha, P (American Chemical Society, 2018-03)

Zerumbone isolated from the rhizomes of Zingiber zerumbet was investigated for the mechanisms by which it exhibits antiproliferative activity in colorectal cancer cells (SW480). The results indicated that the zerumbone ...

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