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Browsing by Author "Jayamurthy, P"

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Advanced Glycation End-products (AGE) Trapping Agents: Design and Synthesis of Nature Inspired Indeno[2,1-c]Pyridinones

Anaga, N; Basavaraja, D; Abraham, B; Nisha, P; Varughese, S; Jayamurthy, P; Sasidhar, B S (Elsevier, 2020-12)

Advanced glycation end products (AGEs) are implicated to be the key players in most of the diabetic complications. The AGE’s interfere with the proteins heterogeneously, thereby rendering denaturation and the consequent ...
A Comparative Evaluation of Antioxidant and Antidiabetic Potential of Peel from Young and Matured Potato

Arun, K B; Chandran, J; Dhanya, R; Krishna, P; Jayamurthy, P; Nisha, P (Elsevier, 2015-03)

In the present study antioxidant and antidiabetic potentials of potato peels at two different stages of maturity were evaluated and compared. Peels of young and mature potatoes (YP and MP) were sequentially extracted ...
A Comparative Study on Antioxidant Activities of Different Varieties of Solanum Melongena

Nisha, P; Abdul Nazar, P; Jayamurthy, P (Elsevier, 2009-10)

Eggplant is one of most common vegetables consumed all around the world. The present study evaluates the antioxidant potential of four different varieties of eggplant (long green, purple coloured big size, purple coloured ...
Comparative study on the total phenolic content and radical scavenging activity of common edible vegetable oils

Janu, C; Soban Kumar, D R; Reshma, M V; Jayamurthy, P; Sundaresan, A; Nisha, P (John Wiley, 2014)

The study investigates the antioxidant potential of commonly used vegetable oils viz., coconut (CNO), sunflower (SFO), rice bran (RBO), groundnut (GNO), sesame (SESO) and mustard oil (MO), where the oils were extracted ...
Effect of enzyme assisted extraction on quality and yield of volatile oil from black pepper and cardamom

Janu, Chandran; Padmakumari Amma, K P; Nirmala Menon, A; Jayamurthy, P; Nisha, P (Springer, 2012)

The present study investigated the effect of enzyme pre-treatment on extraction of active compounds from spices, namely, black pepper and cardamom. A mixture of enzymes, namely, Lumicellulae (a mixture of cellulase, ...
Enhanced Antibacterial Metabolite Production Through the Application of Statistical Methodologies by a Streptomyces Nogalater NIIST A30 Isolated from Western Ghats Forest Soil

Jubi Jacob; Reshma, U R; Syama, H P; Jayamurthy, P; Dileep Kumar, B S (2017-04-24)

Streptomyces strains isolated from Nelliyampathy forest soil of Western Ghats, Kerala, India were evaluated for their antibacterial efficacy against two indicator pathogenic bacteria (Escherichia coli and Staphylococcus ...
Evaluation of antioxidant potential of inflorescence and stalk of plantain (Musa Sapientum)

Jayamurthy, P; Aparna, B; Gayathri, G; Nisha, P (Wiley, 2013)

In the present study, the free radical scavenging capacity and antioxidant activities of methanolic extracts of inflorescence and stem core of plantain (Musa sapientum) were evaluated in terms of total phenolic content, ...
Functionalizable 1H‐Indazoles by Palladium Catalyzed Aza‐Nenitzescu Reaction: Pharmacophores to Donor‐Acceptor Type Multi‐Luminescent Fluorophores

Janardhanan, J C; Mishra, R K; Das, G; Sini, S; Jayamurthy, P; Suresh, C H; Praveen, V K; Narayanapillai, M; Babu, B P (Wiley, 2018-08-23)

Development of small‐molecule‐based multi‐luminescent fluorophores utilizing simple synthetic methodologies, as well as easily available starting materials, has gained much attention in recent years. Herein, we disclose ...
Heteroaromatic donors in donor–acceptor–donor based fluorophores facilitate zinc ion sensing and cell imaging

Sreejith, S; Divya, K P; Jayamurthy, P; Jomon Mathew; Anupama, V N; Divya, S P; Anees, P; Ajayaghosh, A (Royal Society of Chemistry, 2012)

The excited state intra molecular charge transfer (ICT) property of fluorophores has been extensively used for the design of fluorescent chemosensors. Herein, we report the synthesis and properties of three donor–π-acce ...
Hexamethine Hemicyanine Dye as a Thermo-optical Probe for Serum Albumin

Udayan, S; Elizebath, D; Sherin, D R; Praveen, V K; Sunny, S; Jayamurthy, P; Manojkumar, T K; Nampoori, V P N; Thomas, S (Elsevier, 2021)

In the present work, we demonstrate the usefulness of a hexamethine hemicyanine dye as a thermo-optical probe for serum albumin, an abundant transport protein in the circulatory system, and its optimum concentration is ...
In Vitro Evaluation of Antidiabetic Potential of Hesperidin and its Aglycone Hesperetin Under Oxidative Stress in Skeletal Muscle Cell Line

Dhanya, R; Jayamurthy, P (Wiley, 2020-06)

The present study investigates the in vitro antidiabetic and antioxidant potential of hesperidin and hesperetin under oxidative stress induced in L6 myotubes. Also, the study attempts to reveal the effect of glycosylation ...
Inhibitory effect of Terminalia chebula Retz. fruit extracts on digestive enzyme related to diabetes and oxidative stress

Indu Sasidharan; Sundaresan, A; Nisha, V M; Mahesh, S K; Raghu, K G; Jayamurthy, P (Informa, 2012)

Terminalia chebula fruit extracts were prepared sequentially with hexane, ethyl acetate, methanol and methanol– water (70:30) and tested for their α-glucosidase inhibitory and antioxidant potential. The study resulted in ...
Modulation of hypoxia-induced pulmonary vascular leakage in rats by Seabuckthorn (Hippophae rhamnoides L.)

Jayamurthy, P; Geetha, S; Shukla, D; Himani Jayamurthy; Kasiganesan, H; Kumar, R; Sawhney, R C (Hindawi Publishing Corporation, 2011)

Cerebral and pulmonary syndromes may develop in unacclimatized individuals shortly after ascent to high altitude resulting in high altitude illness, which may occur due to extravasation of fluid from intra to extravascular ...
New 1,2-Dihydropyridine-Based Fluorophores and Their Applications as Fluorescent Probes

Jamsheena, V; Mishra, R K; Veena, K S; Sini, S; Jayamurthy, P; Lankalapalli, R S (American Chemical Society, 2018-01-24)

New 1,2-dihydropyridine (1,2-DHP)-based fluorophores 1a−1h were designed and synthesized by a one-pot four-component condensation reaction using dienaminodioate, aldehydes, and an in situ-generated hydrazone mediated by ...
Plantain peel - a potential source of antioxidant dietary fibre for developing functional cookies

Arun, K B; Persia, F; Aswathy, P S; Janu, C; Sajeev, M S; Jayamurthy, P; Nisha, P (Springer, 2015-10)

Plantain cultivar Nendran is popular as a staple food in many parts of India and deep fried chips made from raw matured Nendran are one of the popular snack items in India. This study aims to utilize peel from Nendran ...
Preconditioning L6 muscle cells with Naringin ameliorates oxidative stress and increases glucose uptake

Dhanya, R; Arun, K B; Nisha, V M; Syama, H P; Nisha, P; Santhosh Kumar, T R; Jayamurthy, P (PLOS, 2015-07-06)

Enhanced oxidative stress contributes to pathological changes in diabetes and its complications. Thus, strategies to reduce oxidative stress may alleviate these pathogenic processes. Herein, we have investigated Naringin ...
Promalabaricone B from Myristica Fatua Houtt. Seeds Demonstrate Antidiabetic Potential by Modulating Glucose Uptake via the Upregulation of AMPK in L6 Myotubes

Prabha, B; Sini, S; Sherin, D R; Neethu, S; Rameshkumar, K B; Manojkuma, T K; Jayamurthy, P; Radhakrishnan, K V (Taylor & Francis, 2021-03-04)

Promalabaricone B (PMB), an acylphenol was isolated from dichloromethane-soluble extract of the seeds of Myrisitica fatua Houtt. PMB exhibited significant inhibitory activity on a-glucosidase enzyme. The molecular docking ...
Quantification of Phenolics in Syzygium Cumini Seed and their Modulatory Role on Tertiary Butyl-Hydrogen Peroxide-Induced Oxidative Stress in H9c2 Cell Lines and Key Enzymes in Cardioprotection

Syama, H P; Arya, A D; Dhanya, R; Nisha, P; Sundaresan, A; Jacob, E; Jayamurthy, P (Springer, 2017-06)

The study quantified the major phenolics in different fractions of Syzygium cumini seeds and evaluated their cardioprotective efficacy. Gallic acid, ellagic acid, cinnamic acid, quercetin, syringic acid and ferulic acid ...
Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line

Dhanya, R; Arya, A D; Nisha, P; Jayamurthy, P (Frontiers Media, 2017-06-08)

Herein we investigated the molecular mechanism of action of the citrus flavonoid, quercetin in skeletal muscle cells (L6 myotubes). Taking advantage of protein kinase inhibitors, we proved that the effect of quercetin on ...
Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide

Dhanya, R; Arun, K B; Syama, H P; Nisha, P; Sundaresan, A; Santhosh Kumar, T R; Jayamurthy, P (Elsevier, 2014)

Scientific evidence suggests a strong link between the oxidative stress-induced pathways and onset of diabetes and its complications. The present study evaluates the antidiabetic potential of the flavonoids, rutin and its ...

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