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Browsing by Author "Joseph, M M"

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Biogenic Cluster-Encased Gold Nanorods as a Targeted Three-in-One Theranostic Nanoenvelope for SERS-Guided Photochemotherapy against Metastatic Melanoma

Sujai, P T; Joseph, M M; Karunakaran, V; Saranya, G; Adukkadan, R N; Shamjith, S; Thomas, R; Nair, J B; Swathi, R S; Maiti, K K (American Chemical Society, 2019-01-22)

Effective treatment of malignant melanoma requires an appropriate combination of therapeutic intervention with long-term prognosis as it often survives by monotherapies. Herein, we report a novel melanoma-targeted theranostic ...
Biogenic silver nanoparticles embedded polyvinyl alcohol nanofibrous scaffolds avert tumour and bacterial growth

Preethi, G U; Unnikrishnan, B S; Shiji, R; Sreelekha, T T; Joseph, M M (Current Science, 2019-05-17)

This communication describes a carefully designed strategy which blends biogenic silver nanoparticles with PVA scaffolds to fabricate SNP@PVA electrospun scaffolds with admirable physico-chemical properties. The hybrid ...
Bisindole-Oxadiazole Hybrids, T3P®-Mediated Synthesis, and Appraisal of Their Apoptotic, Antimetastatic, and Computational Bcl-2 Binding Potential

Pooja, R K; Joseph, M M; Abdul Salam, A A; Sreelekha, T T; Dhanya, S; Biswas, S; Pai, K S R (Wiley, 2017-11)

In the pursuit of novel anticancer leads, new bisindole-oxadiazoles were synthesized using propyl phosphonic anhydride as a mild and efficient reagent. The molecule, 3-[5-(1H-indol-3-ylmethyl)- 1,3,4-oxadiazol-2-yl]-1H-indole ...
Cationic Donor–Two-Acceptor Dye–Graphene Quantum Dot Nanoconjugate for the Ratiometric Detection of Bisulfite Ions and Monitoring of SO2 Levels in Heat-Stressed Cells

Hiremath, S D; Thakuri, A; Joseph, M M; Bhosle, A A; Maiti, K K; Banerjee, M; Chatterjee, A (ACS Publications, 2023-06-09)

When the body temperature rises above 40.6 °C, heat stress in the cells causes mitochondrial damage. This damage can lead to apoptosis, multiple organ failure, and even death. The dysregulation of SO2 levels in the ...
Computational and Mechanistic Studies on the Effect of Galactoxyloglucan: Imatinib Nanoconjugate in Imatinib Resistant K562 Cells

James, A R; Unnikrishnan, B S; Priya, R; Joseph, M M; Manojkumar, T K; Raveendran Pillai, K; Shiji, R; Preethi, G U; Kusumakumary, P; Sreelekha, T T (Sage Publications, 2017-03)

Imatinib mesylate, a BCR/ABL fusion protein inhibitor, is the first-line treatment against chronic myelogenous leukemia. In spite of its advantageous viewpoints, imatinib still has genuine impediments like undesirable side ...
Elucidating a Thermoresponsive Multimodal Photo-Chemotherapeutic Nanodelivery Vehicle to Overcome the Barriers of Doxorubicin Therapy

Nair, J B; Joseph, M M; Arya, J S; Sreedevi, P; Sujai, P T; Maiti, K K (ACS Publications, 2020)

In an attempt to circumvent the major pitfalls associated with conventional chemotherapy including drug resistance and off-target toxicity, we have adopted a strategy to simultaneously target both mitochondrial DNA ...
Emergence of Gold-Mesoporous Silica Hybrid Nanotheranostics: Dox-Encoded, Folate Targeted Chemotherapy with Modulation of SERS Fingerprinting for Apoptosis Toward Tumor Eradication

Ramya, A N; Joseph, M M; Santhi, M; Varsha, K; Sreelekha, T T; Maiti, K K (Wiley, 2017-08-18)

Strategically fabricated theranostic nanocarrier delivery system is an unmet need in personalized medicine. Herein, this study reports a versatile folate receptor (FR) targeted nanoenvelop delivery system (TNEDS) fabricated ...
Endogenous H2S‑Assisted Cancer-Cell-Speciﬁc Activation of Theranostics with Emission Readout

Bobba, K N; Saranya, G; Sujai, P T; Joseph, M M; Velusamy, N; Podder, A; Maiti, K K; Bhuniya, S (American Chemical Society, 2019-02-20)

Realizing the importance of activation of the anticancer drug, its distribution, and for cancer management, a new theranostic probe has been developed. Endogenous H2S stimulated the theranostic molecular prodrug (TP-HS) ...
Enzyme-Driven Switchable Fluorescence-SERS Diagnostic Nanococktail for the Multiplex Detection of Lung Cancer Biomarkers

Saranya, G; Joseph, M M; Karunakaran, V; Nair, J B; Saritha, V N; Veena, V S; Sujathan, K; Ajayaghosh, A; Maiti, K K (American Chemical Society, 2018-10-24)

Comprehensive profiling of multiple protein targets plays a critical role in deeper understanding of specific disease conditions associated with high heterogeneity and complexity. Herein, we present the design and fabrication ...
Erratum: Bisindole-oxadiazole hybrids, T3P®-mediated synthesis and appraisal of their apoptotic, antimetastatic and computational Bcl‐2 binding potential

Pooja, R K; Joseph, M M; Abdul Salam, A A; Sreelekha, T T; Dhanya, S; Biswas, S; Pai, K S R (Wiley, 2018-08-28)

In the original published article “Bisindole‐oxadiazole hybrids, T3P mediated synthesis and appraisal of their apoptotic, antimetastatic and computational Bcl‐2 binding potential” by Kamath et al, 2017, J Biochem Mol ...
Exploration of Biogenic Nano-chemobiotics Fabricated by Silver Nanoparticle and Galactoxyloglucan with an Efficient Biodistribution in Solid Tumor Investigated by SERS Fingerprinting

Joseph, M M; Nair, J B; Adukkadan, R N; Neethu, H; Pillai, R K; Nair, A J; Maiti, K K; Sreelekha, T T (American Chemical Society, 2017-05-23)

An incredible exploration ensued of a dual modality nanocomposite wherein chemotherapy in fusion with antibacterial efficacy is obtained in a biogenic fabrication, which transformed as a novel nano-chemobiotics (NCB) ...
Guanidinium Rich Dendron-Appended Hydnocarpin Exhibits Superior Anti-Neoplastic Effects Through Caspase Mediated Apoptosis

Mathai, B M; Joseph, M M; Santhi, M; Jyothi, B N; Arya, J S; Varsha, K; Radhakrishnan, K V; Maiti, K K (Royal Society of Chemistry, 2016-05-20)

Medicinal plants have truly demonstrated their potential as a repository of active biomolecules with promising therapeutic potential and represent an important source for the identification of novel drug leads. Hydnocarpus ...
Nanotheranostic Probe Built on Methylene Blue Loaded Cucurbituril [8] and Gold Nanorod: Targeted Phototherapy in Combination with SERS Imaging on Breast Cancer Cells

Narayanan, N; Kim, J H; Santhakumar, H; Joseph, M M; Karunakaran, V; Shamjith, S; Saranya, G; Sujai, P T; Jayasree, R S; Barman, I; Maiti, K K (American Chemical Society, 2021-12-06)

Recent advancements in a nanoarchitecture platform for safe and effective targeted phototherapy in a synergistic fashion is an absolute necessity in localized cancer therapy. Photothermal and photodynamic therapies (PTT ...
De Novo Design and Synthesis of Boomerang-Shaped Molecules and Their in Silico and SERS-Based Interactions with SARS-CoV-2 Spike Protein and ACE2

Linet, A; Joseph, M M; Haritha, M; Shamna, K; Varughese, S; Devi, P S; Suresh, C H; Maiti, K K; Neogi, I (Royal society of chemistry, 2021)

The recent outbreak of the COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which infects human epithelial tissue by interaction of the receptor-binding domain of its spike ...
pH-Controlled Nanoparticles Formation and Tracking of Lysosomal Zinc Ions in Cancer Cells by Fluorescent Carbazole–Bipyridine Conjugates

Sudheesh, K V; Joseph, M M; Divya, S P; Samanta, A; Maiti, K K; Ajayaghosh, A (Wiley, 2018-02-28)

Fluorescent probes for simultaneous detection of multiple organelle specific analytes in cancer cells are essential for bioimaging applications. During abnormalities in cells, among other important parameters (metal ions, ...
Plasmonically Enhanced Galactoxyloglucan Endowed Gold Nanoparticles Exposed Tumor Targeting Biodistribution Envisaged in a Surface-Enhanced Raman Scattering Platform

Joseph, M M; Nair, J B; Maiti, K K; Sreelekha, T T (American Chemical Society, 2017-11-15)

Biopolymer-capped gold nanoparticles (AuNPs) were perceived for tracing biodistribution in a solid tumor mice through surface-enhanced Raman scattering (SERS) fingerprinting. In this strategy, a robust and ecofriendly green ...
A Ratiometric Near-Infrared Fluorogen for the Real Time Visualization of Intracellular Redox Status during Apoptosis

Saranya, G; Anees, P; Joseph, M M; Maiti, K K; Ajayaghosh, A (Wiley, 2017-05-29)

Direct monitoring of apoptotic progression is a major step forward for the early assessment of therapeutic efficacy of certain treatments and the accurate evaluation of the spread of a disease. Here, the regulatory role ...
Tracking the Footprints of Paclitaxel Delivery and Mechanistic Action via SERS Trajectory in Glioblastoma Cells

Nair, J B; Mohapatra, S; Joseph, M M; Maniganda, S; Gupta, V; Ghosh, S; Maiti, K K (ACS Publications, 2020-09-14)

The design and development of an efficacious tumor-specific drug-delivery system is a challenging task. In this study, we have synthesized target-specific small peptide substrates on an octaguanidine sorbitol scaffold, ...

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