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Browsing by Author "Jubi John"

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Accessing Highly Functionalized Cyclopentanoids: Via a Cascade Palladation Approach: Unprecedented Benzylic C-H Activation Towards Cyclopentenoindanes

Santhini, P V; Smrithy, A S; Irfana Jesin, C P; Sunil Varughese; Jubi John; Radhakrishnan, K V (The Royal Society of Chemistry, 2018-02-23)

A Pd-catalyzed synthesis of 3,4,5-trisubstituted cyclopentenes from diazabicyclic olefins and o-iodobenzoates has been developed. The hitherto unknown cascade process involves three stages: carbopalladation, oxypalladation ...
A Bentonite–gold Nanohybrid as a Heterogeneous Green Catalyst for Selective Oxidation of Silanes

Maya, R J; Jubi John; Luxmi Varma, R (Royal Society of Chemistry, 2016-08-01)

A highly efficient, environmentally benign and reusable heterogeneous bentonite–gold nanohybrid catalyst was designed and synthesized. This heterogeneous catalyst could efficaciously catalyse the oxidation of organosilanes ...
CATALYTIC DESYMMETRIZATION OF DIAZABICYCLIC OLEFINS: A HIGHLY STEREOSELECTIVE STRATEGY TOWARDS FUNCTIONALIZED CYCLOPENTANOIDS

Radhakrishnan, K V; Jubi John; Rani Rajan; Nayana Joseph (spinger science, 2010-12)

One of the most important goals in contemporary synthetic organic chemistry is the development of stereoselective carbon–carbon coupling reactions providing a broadly applicable method to synthesize complex structures ...
Desymmetrization of meso-Bicyclic Hydrazines: An Efficient Strategy Towards the Synthesis of Functionalized Cyclopentenes

Sajisha, V S; Anas, S; Jubi John; Radhakrishnan, K V (Thieme, 2009)

Desymmetrization of meso-bicyclic hydrazines offers a facile entry into the class of functionalized cyclopentenes. Various methodologies used along this direction are described in this account. Our attempts in this area ...
Direct Reductive Amination of Aldehydes via Environmentally Benign Bentonite-Gold Nanohybrid Catalysis

Maya, R J; Susanna, P; Jubi John; Luxmi Varma, R (Wiley, 2017-04-03)

An efficient, green and reliable method for the direct reductive amination of aldehydes was developed using an environmentally benign bentonite-gold nanohybrid catalyst. Use of this heterogeneous catalyst affords a variety ...
An exclusive approach to 3,4-disubstituted cyclopentenes and alkylidene cyclopentenes via the palladium catalyzed ring opening of azabicyclic olefins with aryl halides

Nayana Joseph; Rani Rajan; Jubi John; Devika, N V; Sarath Chand, S; Suresh, E; Pihko, P M; Radhakrishnan, K V (Royal Society of Chemistry, 2013)

A simple and efficient method for the stereoselective ring opening of bicyclic hydrazines with various aryl halides under palladium catalysis has been elaborated. The reactions afforded trans-3,4-disubstituted cyclopentenes ...
Facile synthesis of alkylidene cyclopentenes via palladium catalyzed ring opening of fulvene derived bicyclic hydrazines

Anas, S; Sajisha, V S; Jubi John; Nayana Joseph, J; Sholly, C G; Radhakrishnan, K V (Elsevier, 2008)

A facile synthesis of substituted alkylidene cyclopentenes through a palladium catalyzed ring opening of fulvene derived bicyclic hydrazines with various organometallic reagents is described. The products are versatile ...
Heteroannulation of 3‑Nitroindoles and 3‑Nitrobenzo[b]thiophenes: A Multicomponent Approach toward Pyrrole-Fused Heterocycles

Santhini, P V; Sheba Ann, B; Akhil Krishnan, R; Suresh, E; Jubi John (American Chemical Society, 2017-05-05)

A simple, efficient, and general multicomponent reaction involving an enolizable ketone, a primary amine, and an N-protected 3-nitroindole was developed for the synthesis of a range of functionalized pyrrolo [3,2-b]indoles. ...
Inhibition of Glutamate Decarboxylase (GAD) by Ethyl Ketopentenoate (EKP) Induces Treatment-resistant Epileptic Seizures in Zebrafish

Zhang, Y; Vanmeert, M; Siekierska, A; Annelii, N; Jubi John; Callewaert, G; Eveline, L; Dehaen, W; De Witte, P A M; Kaminski, R M (Nature, 2017-08-03)

Epilepsy is a chronic brain disorder characterized by recurrent seizures due to abnormal, excessive and synchronous neuronal activities in the brain. It affects approximately 65 million people worldwide, one third of which ...
Iodine assisted modified Suzuki type reaction of bicyclic hydrazines: stereoselective synthesis of functionalized cyclopentenes

Jubi John; Sajisha, V S; Smitha Mohanlal; Radhakrishnan, K V (Royal Society Chemistry, 2006)
One-Pot MCR-Oxidation Approach toward Indole-Fused Heteroacenes

Santhini, P V; Akhil Krishnan, R; Sheba Ann, B; Betna, S S; Das, G; Praveen, V K; Sunil Varughese; Jubi John (American Chemical Society, 2017-09-14)

A straightforward synthetic route toward indole-fused heteroacenes was developed. The strategy is composed of a one-pot process starting with a multicomponent reaction of cyclohexanone, primary amine and N-tosyl-3-nitroindole ...
Palladium catalyzed reaction of ortho-functionalized aryl iodides with bicyclic hydrazines: facile route toward heteroannulated cyclopentenes and azabicycles

Jubi John; Rani, R; Sarath Chand, S; Praveen, P; Nayana Joseph; Suresh, E; Radhakrishnan, K V (Elsevier, 2013)

A palladium catalyzed tandem protocol for the synthesis of cyclopentene fused heterocycles from diazabicyclic alkenes and ortho-functionalized aryl iodides has been elaborated. This tandem protocol was utilized for the ...
Palladium catalyzed ring opening of azabicyclic olefins with organoindium and gallium reagents: a facile access towards benzylated cyclopentanoids

Jubi John; Adarsh, B; Radhakrishnan, K V (Elsevier, 2010)

Palladium catalyzed desymmmetrization of diazabicyclic olefins with organoindium and gallium reagents were examined These reactions provided an easy access to trans-3,4-disubstituted cyclopentenes in good to excellent ...
Palladium catalyzed tandem ring opening-ring closing reaction of diazabicyclic alkenes: A facile one pot strategy for cyclopentannulation of heterocycles

Jubi John; Indu, U; Suresh, E; Radhakrishnan, K V (American Chemical Society, 2009)

A novel palladium catalyzed protocol for the synthesis of cyclopentene fused heterocycles from diazabicyclic alkenes and ortho-functionalized aryliodides has been elaborated. The reaction can be tuned toward the formation ...
Palladium-catalyzed bis-functionalization of isatylidenes: A facile route towards spiro-indol-2-ones

George, S C; Jubi John; Anas, S; Joshni John; Yamamoto, Y; Suresh, E; Radhakrishnan, K V (Wiley, 2010)

An effective protocol has been developed for the construction of 3,3-disubstituted indol-2-ones from isatylidenes by utilizing amphiphilic bis-pi-allylpalladium and related intermediates. The developed strategy is a new ...
Pd-Catalyzed Oxidative Annulation of Enamides with Diazabicyclic Olefins: Rapid Access to Cyclopentene Fused 2-Pyrrolines

Santhini, P V; Nimisha, G; Jubi John; Suresh, E; Luxmi Varma, R; Radhakrishnan, K V (Royal Society of Chemistry, 2017-02-07)

An efficient stereoselective route for the synthesis of cyclopentene fused 2-pyrrolines has been established via a Pd-catalyzed C–H activation/oxidative coupling of aryl enamides with diazabicyclic olefins. The proposed ...
Sequential Tandem Transformations of Functionalized Diazanorbornenes: Facile Strategy towards Pentacyclic Frameworks with Multiple Stereocenters

Preethanuj, P; Jijitha, V; Ajesh, V; Jubi John; Radhakrishnan, K V (Thieme, 2017-04)

The design, synthesis, and comprehensive utilization of diazanorbornene systems incorporating a flexible hydroxy group are described. The Lewis acid catalyzed intramolecular rearrangement of these strained alkenes gave ...
Sequential Ugi Reaction/Base-induced Ring Closing/IAAC Protocol Toward Triazolobenzodiazepine-fused Diketopiperazines and Hydantoins

Robby, V; Bamba, F; Jonas, W; Joice, T; Jeroen, J; Meervelt, L V; Jubi John; Wim, D (Beilstein-Institut, 2018-03-14)

A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which ...
Tandem organocatalyzed Knoevenagel condensation/1,3-dipolar cycloaddition towards highly functionalized fused 1,2,3-triazoles

Jubi John; Joice Thomas; Parekh, N; Dehaen, W (Wiley-V C H, 2015)

Facile synthesis of fused 1,2,3-triazoles by a proline-catalyzed reaction of an azido aldehyde and a nitroalkane is elaborated. The present tandem protocol proceeds via an organocatalytic Knoevenagel condensation of the ...
Transition metal catalyzed carboannulation of diazabicyclic alkenes with ambiphilic bifunctional reagents: A facile route towards functionalized indanones and indanols

Nayana Joseph; Jubi John; Rani, R; Sreeja, T; Anupa, M; Suresh, E; Radhakrishnan, K V (Elsevier, 2011)

Functionalized indanones are readily prepared in good to excellent yields by the Pd/Rh catalyzed carboannulation of bicyclic and tricyclic hydrazines with 2-iodobenzonitrile, 2-cyanophenylboronic acid and 2-formylphenylboronic ...

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