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Browsing by Author "Jyothi, B N"

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A Dual-Targeting Octaguanidine–Doxorubicin Conjugate Transporter for Inducing Caspase-Mediated Apoptosis on Folate-Expressing Cancer Cells

Jyothi, B N; Manu M, Joseph; Saswat, Mohapatra; Safeera, M; Surajit, Ghosh; Sreelekha, T T; Maiti, Kaustabh Kumar (wiley, 2016-03-04)

An efficient synthetic framework was assembled (G8-FKE-FADox), consisting of a lysosome-targeting octaguanidine molecular transporter with a cathepsin B (cath B)-specific peptide substrate, folic acid, and the potent ...
Guanidinium Rich Dendron-Appended Hydnocarpin Exhibits Superior Anti-Neoplastic Effects Through Caspase Mediated Apoptosis

Mathai, B M; Joseph, M M; Santhi, M; Jyothi, B N; Arya, J S; Varsha, K; Radhakrishnan, K V; Maiti, K K (Royal Society of Chemistry, 2016-05-20)

Medicinal plants have truly demonstrated their potential as a repository of active biomolecules with promising therapeutic potential and represent an important source for the identification of novel drug leads. Hydnocarpus ...
A lysosome-targeted drug delivery system based on sorbitol backbone towards efficient cancer therapy

Santhi, M; Vandana, S; Jyothi, B N; Raghu, K G; Maiti, K K (Royal Society of Chemistry, 2014)

A straightforward synthetic approach was adopted for the construction of a lysosome-targeted drug delivery system (TDDS) using sorbitol scaffold (Sor) linked to octa-guanidine and tetrapeptide GLPG, a peptide substrate of ...
New Insight of Tetraphenylethylene-based Raman Signatures for Targeted SERS Nanoprobe Construction Toward Prostate Cancer Cell Detection

Ramya, A N; Manu M, Joseph; Jyothi, B N; Varsha, Karunakaran; Nisha, Narayanan; Kaustabh Kumar Maiti (ACS publication, 2016-04-06)

We have designed and synthesized novel tetraphenylethylene (TPE) appended organic fluorogens and unfold their unique Raman fingerprinting reflected by surface-enhanced Raman scattering (SERS) upon adsorption on ...

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