The limitation of the CuAAC “click” reaction with a 2-azidopyridine substrate, owing to its equilibrium with a tetrazole isomer, is exploited herein for its utility in the Glaser–Hay reaction. A catalytic combination of a ...

A convergent route for the synthesis of BCX-1777 and BCX-4430 from a Boc-protected 2-pyrrolidinone, derived from 2,3,5-tri-O-benzyl-d-ribonolactone, and a dihalogenated pyrrolopyrimidine as the key starting materials is ...