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Browsing by Author "Prathapan, A"

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Antioxidant, antiglycation and inhibitory potential of saraca ashoka flowers against the enzymes linked to type 2 diabetes and LDL oxidation

Prathapan, A; Nampoothiri, S V; Mini, S; Raghu, K G (Verduci Editore, 2012)

Objective: The present study investigated the antioxidant, antiglycation and inhibitory potential of flavonoid fraction of Saraca ashoka flowers (SAF) against α-glucosidase and α-amylase (the enzymes linked to type 2 ...
Antiperoxidative, free radical scavenging and metal chelating activities of Boerhaavia diffusal.

Prathapan, A; Singh, M K; Anusree, S S; Soban Kumar, D R; Sundaresan, A; Raghu, K G (Wiley, 2011)

Boerhaavia diffusa, a green leafy vegetable and medicinal plant as whole was traditionally used in treating different ailments due to its multiple pharmacological activities viz., immuno suppressant, anti-diabetic, analgesic, ...
Apoptosis In Angiotensin II-Stimulated Hypertrophic Cardiac Cells -Modulation By Phenolics Rich Extract Of Boerhavia Diffusa L.

Prathapan, A; Salin Raj, P; Priya, Rani M; Raghu, K G (Elsevier, 2018-12)

Herein, we investigated the effects of B. diffusa (BDE), a well-known cardiotonic edible medicinal plant against apoptosis in Angiotensin II (Ang II)-stimulated hypertrophic cardiac cells (H9c2). The cells were analyzed ...
Arsenic trioxide toxicity in H9c2 myoblasts-damage to cell organelles and possible amelioration with Boerhavia diffusa

Vineetha, V P; Prathapan, A; Soumya, R S; Raghu, K G (Springer, 2013)

Arsenic trioxide (ATO) has been long used as a chemotherapeutic agent because of its significant anticancer property. Unfortunately, the use of ATO is limited due to its cardiotoxic effects. The present study evaluates the ...
Arsenic Trioxide Toxicity in H9c2 Myoblasts—Damage to Cell Organelles and Possible Amelioration with Boerhavia diffusa

Vineetha, V.P; Prathapan, A; Soumya, R.S; Raghu, K.G (Springer Science+Business Media, 2012-11-19)

Arsenic trioxide (ATO) has been long used as a chemotherapeutic agent because of its significant anticancer property. Unfortunately, the use of ATO is limited due to its cardiotoxic effects. The present study evaluates ...
Attenuation of Arsenic Trioxide Induced Cardiotoxicity through Flaxseed Oil in Experimental Rats

Varghese, M V; Abhilash, M; Manju, A; Sauganth Paul, M V; Prathapan, A; Raghu, K G; Nair, R H (Taylor & Francis, 2017-02-17)

Objectives: Arsenic trioxide (As2O3) is a potent drug for acute promyelocytic leukaemia, but its clinical trials are allied with some serious adverse events mainly cardiac functional abnormalities. So the objective of ...
Boerhaavia diffusa L. attenuates angiotensin II-induced hypertrophy in H9c2 cardiac myoblast cells via modulating oxidative stress and down-regulating NF-kBeta and transforming growth factor Beta1

Prathapan, A; Vineetha, V P; Abhilash, P A; Raghu, K G (Cambridge University Press, 2013)

The present study evaluated the antihypertrophic potential of the ethanolic extract of Boerhaavia diffusa (BDE), a well-known edible cardiotonic plant reported in Ayurveda against angiotensin II-induced hypertrophy in ...
Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction

Abhilash, P A; Nisha, P; Prathapan, A; Nampoothiri, S V; Cherian, O L; Sunitha, T K; Raghu, K G (Elsevier, 2011)

The present study evaluated the protective potential of aqueous extract of Oxalis corniculata (OCE) against isoproterenol (ISO) induced myocardial infarction in rats. Myocardial infarction in rats was induced by isoproterenol ...
Chemical composition and in vitro antioxidative potential of essential oil isolated from Curcuma longa L. leaves.

Priya, R; Prathapan, A; Raghu, K G; Nirmala Menon, A (Elsevier, 2012-02)

The objective was to determine the chemical composition and antioxidant potential of essential oil isolated from the leaves of Curcuma longa(turmeric).Chemical composition of the oil was analyzed using GC-MS. Antiperoxidative ...
Effect of heat treatment on curcuminoid, colour value and total polyphenols of fresh turmeric rhizome

Prathapan, A; Lukhman, M; Arumughan, C; Sundaresan, A; Raghu, K G (Wiley, 2009)

Studies were undertaken to examine the effect of heat treatment on total phenolic content (TPC), colour value (yellowishness and brightness), polyphenol oxidase (PPO) activity and curcuminoid of fresh turmeric rhizome. ...
Effect of Sprouting on Antioxidant and Inhibitory Potential of Two Varieties of Bengal Gram (Cicer arietinum L.) Against Key Enzymes Linked to Type-2 Diabetes

Prathapan, A; Fahad, K; Thomas, B K; Riya, M P; Raghu, K G (Informa Health care, 2011-05)

Type 2 diabetes is a chronic metabolic disease, and the current treatment for type 2 diabetes targets oxidative stress and postprandial hyperglycemia via the inhibition of α-glucosidase and α-amylase, key enzymes linked ...
Fructose induces mitochondrial dysfunction and triggers apoptosis in skeletal muscle cells by provoking oxidative stress

Natasha, J; Maurya, C K; Deepti, A; Deepa, R A; Prathapan, A; Raj, P S; Raghu, K G; Shasi, V K; Akhilesh Kumar, T (Springer, 2015)

Mitochondrial dysfunction in skeletal muscle has been implicated in the development of insulin resistance, a major characteristic of type 2 diabetes. There is evidence that oxidative stress results from the increased ...
In vitro antioxidant and inhibitory potential of Terminalia bellerica and Emblica officinalis fruits against LDL oxidation and key enzymes linked to type 2 diabetes

Nampoothiri, S V; Prathapan, A; Cherian, O L; Raghu, K G; Venugopalan, V V; Sundaresan, A (Elsevier, 2011)

The present study evaluated the free radical scavenging capacity and antioxidant potential of different solvent extracts (Hexane (HE), ethyl acetate (EA), methanol (ME), 70% methanol (MW) and Water (WA)) of Terminalia ...
Invitro antioxidant activities of the methanol extract and its different solvent fractions obtained from the fruit pericarp of Terminalia bellerica

Nampoothiri, S V; Binil Raj, S S; Prathapan, A; Abhilash, P A; Arumughan, C; Sundaresan, A (Taylor & Francis, 2011)

Terminalia bellerica has been used as a traditional medicine in a variety of ailments including anaemia, asthma, cancer, inflammation, rheumatism and hypertension. In this study, the free radical scavenging and antioxidant ...
Invitro antiperoxidative, free radical scavenging and xanthine oxidase inhibitory potentials of ethyl acetate fraction of Saraca ashoka flowers

Prathapan, A; Cherian, O L; Nampoothiri, S V; Mini, S; Raghu, K G (Taylor & Francis, 2011)

Saraca ashoka is a widely used medicinal herb claimed to cure many diseases. This study investigated the antiperoxidative, free radical scavenging and xanthine oxidase (XO) inhibitory potential of the ethyl acetate fraction ...
Isolation and densitometric hptlc method for quantification of belleric acid in the fruit pericarp of terminalia bellerica and its formulations

Nampoothiri, S V; Binil Raj, S S; Ranjith, A; Prathapan, A; Sundaresan, A (Research Inst Medicinal Plants, 2011)

For the first time a simple, sensitive, rapid, precise and accurate HPTLC method has been established for quantification of belleric acid in Terminalia bellerica (TB) fruit pericarp and its formulations. Silica gel plates ...
Modulation of adipogenesis and glucose uptake by Curcuma longa extract in 3T3L1 and L6 cell lines - An in vitro study

Prathapan, A; Mahesh, S K; Lekshmi, P C; Raghu, K G; Nirmala Menon, A (Elsevier, 2012)

Objective: To evaluate the effects of ethyl acetate extract of Curcuma longa of glucose uptake and adipogenesis in cell line models. Methods: We used 3 Ta3gLa1i nasntd m Lo6d cuelalltsi otno iwnavse sdtoignaet ew cityhto ...
Modulation of Haloperidol Induced Electrophysiological Alterations on Cardiac Action Potential by Various Risk Factors and Gender Difference

Raghu, K G; Singh, R; Prathapan, A; Yadav, G K (Elsevier, 2009-08-14)

Haloperidol (HPL), well known antipsychotic drug can induce a marked QT prolongation and polymorphic arrhythmias. In this study we evaluated the influence of various induced risk factors such as electrolyte imbalance ...
Parmotrema tinctorum exhibits antioxidant, antiglycation and inhibitory activities against aldose reductase and carbohydrate digestive enzymes: An in vitro study

Salin Raj, P; Prathapan, A; Jomon, S; Antu, K A; Riya, M P; Preetha Rani, M R; Biju, H; Priya, S; Raghu, K G (Taylor & Francis, 2014)

This study evaluated the inhibitory potential of ethyl acetate extract of Parmotrema tinctorum (PTEE), an edible lichen, against aldose reductase (AR) and carbohydrate digestive enzymes such as alpha-glucosidase and ...
Polyphenol Rich Ethanolic Extract From Boerhavia Diffusa L. Mitigates Angiotensin II Induced Cardiac Hypertrophy and Fibrosis in Rats

Prathapan, A; Varghese, M V; Abhilash, S; Salin Raj, P; Mathew, A K; Anupama Nair; Harikumaran Nair, R; Raghu, K G (Elsevier, 2017-03)

Boerhavia diffusa is a renowned edible medicinal plant extensively used against different ailments including heart diseases in the traditional system of medicine in several countries. The present study aims to evaluate the ...

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