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Browsing by Author "Suresh Kumar, M A"

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Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappa B (NF-kappa B) activation and NF-kappa B-regulated gene expression

Ichikawa, H; Mangalam S Nair; Takada, Y; Alan Sheeja, D B; Suresh Kumar, M A; Oommen, O V; Aggarwal, B B (American Association for Cancer Research, 2006)

Purpose: Deoxyelephantopin (ESD) and isodeoxyelephantopin (ESI) are two sesquiterpene lactones derived from the medicinal plant Elephantopus scaber Linn. (Asteraceae). Although they are used for the treatment of a wide ...
Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-Binding activity of NF-kB in colon cancer cells

Suboj, B; Priya, P S; Nandini, R J; Suresh Kumar, M A; Mangalam S Nair; Priya Srinivas; Srinivas, G (Wiley, 2012-06)

Nimbolide, a plant-derived limonoid has been shown to exert its antiproliferative effects in various cell lines. We demonstrate that nimbolide effectively inhibited proliferation of WiDr colon cancer cells through inhibition ...
Pinocembrin triggers bax-dependent mitochondrial apoptosis in colon cancer cells

Suresh Kumar, M A; Mangalam S Nair; Hema, P S; John Mohan; Santhoshkumar, T R (Wiley, 2007)

Bioflavanoids are the major pigments in plants with multitude of biological activities including inhibition of proliferation or induction of apoptosis in tumor cells. Eventhough the safety records of most flavanoids are ...

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