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Apoptosis mediated cytotoxicity induced by isodeoxyelephantopin on nasopharyngeal carcinoma cells

Farha, K; Geetha, B S; Mangalam S Nair; Dhanya, S R; Latha, P G; Remani, P (Asian Journal of Pharmacy, 2013)

Isodeoxyelephantopin (IDOE), a sesquiterpene lactone isolated from chloroform extract of Elephantopus scaber has been shown anticancer effects in various cancer cell lines. In the present study, we investigated the cytotoxic ...
APOPTOSIS MEDIATED CYTOTOXICITY INDUCED BY ISODEOXYELEPHANTOPIN ON NASOPHARYNGEAL CARCINOMA CELLS

FARHA, A K; GEETHA, B S; MANGALAM NAIR, S; DHANYA, S R; LATHA, P G; REMANI, P (2013-10-22)

Isodeoxyelephantopin (IDOE), a sesquiterpene lactone isolated from chloroform extract of Elephantopus scaber has been shown anticancer effects in various cancer cell lines. In the present study, we investigated the cytotoxic ...
Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells

Kabeer, F A; Sreedevi, G B; Mangalam S Nair; Rajalekshmi, D S; Gopalakrishnan, L P; Remani, P (BioMed Central Ltd., 2014)

Isodeoxyelephantopin (IDOE) isolated from Elephantopus scaber L. (Didancao) is used in Chinese medicine for the treatment of some types of cancer. The anti-cancer mechanism of IDOE remains unclear. This study aims to ...
Isodeoxyelephantopin, a Sesquiterpene Lactone Induces ROS Generation, Suppresses NF-κB Activation, Modulates LncRNA Expression and Exhibit Activities Against Breast Cancer

Verma, S S; Rai, V; Awasthee, N; Dhasmana, A; Rajalakshmi, D S; Nair, M S; Gupta, S C (Nature, 2019-11-29)

The sesquiterpene lactones, Isodeoxyelephantopin (IDET) and Deoxyelephantopin (DET) are known to exhibit activities against some cancer types. The activities of these lactones against breast cancer and the molecular bases ...

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