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Browsing by Subject "Transcription factor"

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Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E-2 production in human peripheral blood mononuclear cells

Viji, V; Helen, A; Luxmi Varma, R (Wiley, 2011)

BACKGROUND AND PURPOSE Betulinic acid (BA) is a naturally occurring triterpenoid widely distributed throughout the plant kingdom. We previously reported that BA inhibits lipopolysaccharide (LPS)-induced interleukin-6 ...
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis

Ajaikumar, B K; Ichikawa, H; Preetha Anand; Mohankumar, C J; Hema, P S; Mangalam S Nair; Aggarwal, B B (Amer Assoc Cancer Research, 2008)

Compounds isolated from members of the Zingiberaceae family are traditionally used as a medicine against inflammatory diseases, but little is known about the mechanism. Here, we report the isolation and structural ...
Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway

Prasad, S; Yadav, V R; Chitra, S; Reuter, S; Hema, P S; Mangalam S Nair; Chaturvedi, M M; Aggarwal, B B (American Society for Biochemistry Molecular Biology Inc, 2010)

Crotepoxide (a substituted cyclohexane diepoxide), isolated from Kaempferia pulchra (peacock ginger), although linked to antitumor and anti-inflammatory activities, the mechanism by which it exhibits these activities, is ...
Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappa B (NF-kappa B) activation and NF-kappa B-regulated gene expression

Ichikawa, H; Mangalam S Nair; Takada, Y; Alan Sheeja, D B; Suresh Kumar, M A; Oommen, O V; Aggarwal, B B (American Association for Cancer Research, 2006)

Purpose: Deoxyelephantopin (ESD) and isodeoxyelephantopin (ESI) are two sesquiterpene lactones derived from the medicinal plant Elephantopus scaber Linn. (Asteraceae). Although they are used for the treatment of a wide ...
Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products

Harikumar, K B; Sung, B; Sheeja, T T; Pandey, M K; Beena Joy; Guha, S; Sunil, K; Aggarwal, B B (American Association of Cancer Research, 2010)

Agents that are safe, affordable, and efficacious are urgently needed for the prevention of chronic diseases such as cancer. Sesamin, a lipid-soluble lignan, is one such agent that belongs to a class of phytoestrogens, ...

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