Pyridine core activation via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adduct of isatin and pyridine: Synthesis of 3-spirodihydroindolizine oxindoles

Baby Viswambharan; Selvakumar, K; Suchithra, M; Shanmugam, P

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dc.contributor.author	Baby Viswambharan
dc.contributor.author	Selvakumar, K
dc.contributor.author	Suchithra, M
dc.contributor.author	Shanmugam, P
dc.date.accessioned	2014-01-07T09:14:39Z
dc.date.available	2014-01-07T09:14:39Z
dc.date.issued	2010
dc.identifier.citation	Organic Letters 12(9):2108-2111;07 May 2010	en_US
dc.identifier.issn	1523-7060
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/1007
dc.description.abstract	An activation of the pyridine nucleus has been achieved via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adducts of isatin and pyridine under basic conditions. The method has been successfully Applied for an efficient synthesis of a number of 3-spirodihydroindolizine-2-oxindoles, which have been found as core structure of secoyohimbane and heteroyohimbane alkaloid natural products.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Analogs	en_US
dc.subject	Cycloaddition	en_US
dc.subject	Natural-products	en_US
dc.subject	Alkaloids	en_US
dc.subject	Spirotryprostatin-A	en_US
dc.subject	Efficient synthesis	en_US
dc.subject	Stereocontrolled synthesis	en_US
dc.subject	Stereoselective-synthesis	en_US
dc.subject	Azomethine ylides	en_US
dc.subject	Asymmetric total-synthesis	en_US
dc.title	Pyridine core activation via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adduct of isatin and pyridine: Synthesis of 3-spirodihydroindolizine oxindoles	en_US
dc.type	Article	en_US