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Metabolite signature of developmental foregut cyst on in vivo and in vitro 1 H MR spectroscopy

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dc.contributor.author Santhosh, K
dc.contributor.author Bejoy Thomas
dc.contributor.author Luxmi Varma, R
dc.contributor.author Sandhyamany, S
dc.contributor.author Kesavadas, C
dc.contributor.author Appukuttan, P S
dc.contributor.author Srinivas, G
dc.contributor.author Gupta, A K
dc.contributor.author Kapilamoorthy, T R
dc.contributor.author Unnikrishnan, M
dc.date.accessioned 2014-05-22T06:28:28Z
dc.date.available 2014-05-22T06:28:28Z
dc.date.issued 2008
dc.identifier.citation Journal of Magnetic Resonance Imaging 28(2):493-496;Aug 2008 en_US
dc.identifier.issn 1053-1807
dc.identifier.uri http://ir.niist.res.in:8080/jspui/handle/123456789/1429
dc.description.abstract Foregut duplication cysts are developmental anomalies of the bronchopulmonary foregut and are common cystic lesions of the mediastinum. We describe a case of mediastinal foregut duplication cyst with in vivo H-1 MR spectroscopy on a 1.5T magnet showing a large metabolite peak at 2.02 ppm, attributable to N-acetylated compounds, in addition to a smaller peak at 1.33 ppm, considered to represent lipids. In vitro NMR spectroscopy (7.05T) of cyst fluid confirmed the presence of these peaks. In addition; a broad multiplet centered at 3.7 ppm, possibly from various protons of the hexose ring system, was also noted. Chemical analysis of the cyst fluid demonstrated the presence of N-acetylhexosamines, proteins, and lipids: Again, in vitro spectra of pure samples of N-acetylglucosamine and N-acetylgalactosamine were obtained for comparison, which better resolved the N-acetyl peak and the peaks at 3.7 ppm. The mucus secreted by respiratory epithelium and the mucous glands of the foregut cysts contains glycoproteins that have N-acetylhexosamines as components and lipid breakdown products that are thought to contribute to the observed spectrum. This information might be useful in predicting the cyst content and, in turn, the lining of the epithelium and the glandular elements. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Foregut duplication cysts en_US
dc.subject MR spectroscopy en_US
dc.subject Fine-needle-aspiration en_US
dc.subject Bronchogenic cyst en_US
dc.subject Mediastinal masses en_US
dc.title Metabolite signature of developmental foregut cyst on in vivo and in vitro 1 H MR spectroscopy en_US
dc.type Article en_US


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