A facile and efficient synthesis of highly functionalised 3,3 '-dispiropyrrolidine- and 3,3 '-dispiropyrrolizidine bisoxindoles via [3+2] cycloaddition

Abstract

The [3+2] cycloaddition reaction of azomethine ylides with isomerised Morita-Baylis-Hillman adducts, both dipoles and dipolarophiles are derived from isatin, afforded highly functionalised 3,3'-dispiro pyrrolidine- and 3,3'-dispiropyrrolizidine bisoxindoles in high yields.