Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of alpha-glucosidase inhibitors

dc.contributor.author	Ajish, K R
dc.contributor.author	Dhanya, B P
dc.contributor.author	Nayana Joseph
dc.contributor.author	Priya Rani, M
dc.contributor.author	Raghu, K G
dc.contributor.author	Vineetha, V P
dc.contributor.author	Radhakrishnan, K V
dc.date.accessioned	2014-05-26T08:42:35Z
dc.date.available	2014-05-26T08:42:35Z
dc.date.issued	2014
dc.identifier.citation	Tetrahedron Letters 55(3):665-670;15 Jan 2014	en_US
dc.identifier.issn	0040-4039
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/1454
dc.description.abstract	A new strategy for the synthesis of novel zerumbone derivatives via a regioselective palladium catalyzed decarboxylative coupling reaction using arene carboxylic acids is described. The current methodology involves the repositioning of endocyclic double bond to exocyclic double bond of zerumbone. Preliminary in vitro analysis revealed that most of the newly synthesized derivatives are potent alpha-glucosidase enzyme inhibitors.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier Science	en_US
dc.subject	Zerumbone	en_US
dc.subject	Zingiber zerumbet	en_US
dc.subject	Palladium	en_US
dc.subject	Decarboxylative coupling	en_US
dc.subject	Alpha-Glucosidase inhibitors	en_US
dc.title	Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of alpha-glucosidase inhibitors	en_US
dc.type	Article	en_US