Abstract:
We describe herein the design, synthesis, and pharmacological evaluation of novel series of imidazolopyridinyl indole analogues as potent antioxidants and antimicrobials. These novel compounds (3a-i) were synthesized by reacting 3,5-disubstituted-indole-2-carboxylic acid (1a-i) with 2,3-diamino pyridine (2) in excellent yield. The novel products were confirmed by their IR, H-1 NMR, C-13 NMR, mass spectral, and analytical data. These compounds were screened for their antioxidant and antimicrobial activities. Among the compounds tested, 3a-d showed the highest total antioxidant capacity, scavenging, and antimicrobial activities. Compounds 3c-d and 3g-h have shown excellent ferric reducing activity.
