A mini library of novel triazolothiadiazepinylindole analogues: Synthesis, antioxidant and antimicrobial evaluations

Abstract

A new series of novel triazolothiadiazepinylindole analogues were synthesized with an aim to examine possible antioxidant and antimicrobial activities. The titled compounds (3a-z) were obtained in good yield by reacting 5-(5-substituted-3-phenyl-1H-indol-2-yl)-4-amino-4H-1,2,4-triazole-3-thiols 1a-c with 3-(2,5-disubstituted-1H-indol-3-yl)-1(4-substituted phenyl) prop-2-en-1-ones 2a-i. All the newly synthesized compounds were characterized by IR, H-1 NMR, mass spectroscopic and analytical data. The synthesized analogues were tested for antioxidant and antimicrobial potency. Among the tested compounds 3a-c and 3j-l have shown very promising free radical scavenging activity and total antioxidant capacity. Compounds 3d-f, 3m-o, and 3s-z have shown excellent ferric reducing antioxidant activity. An outstanding antimicrobial activity is observed with compounds 3a-c and 3j-l.