Abstract:
This study evaluated the inhibitory potential of ethyl acetate extract of Parmotrema tinctorum (PTEE), an edible lichen, against aldose reductase (AR) and carbohydrate digestive enzymes such as alpha-glucosidase and alpha-amylase. It was also screened for antioxidant activities by using DPPH, ABTS, superoxide and hydroxyl radical-scavenging assays. PTEE exhibited alpha-glucosidase, alpha-amylase and AR inhibition along with significant antiglycation potential with an estimated IC50 value of 58.45±1.24, 587.74±3.27, 139.28±2.6 and 285.78±1.287mug/mL, respectively. Antioxidant activity of PTEE against DPPH (IC50 396.83±2.98mug/mL), ABTS (151.34±1.79mug/mL), superoxide (30.29±1.17mug/mL) and hydroxyl (35.42±1.22mug/mL) radicals suggests the antioxidant potential of P. tinctorum. Significant antioxidant activity and inhibitory potential against carbohydrate digestive enzymes and AR suggest that P. tinctorum can be developed as functional food/nutraceuticals for diabetes after detailed study.
