Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam

dc.contributor.author	Gorantla, J N
dc.contributor.author	Jamsheena, V
dc.contributor.author	Lekshmi R Nath
dc.contributor.author	Anto, R J
dc.contributor.author	Ravi S Lankalapalli
dc.date.accessioned	2014-09-17T09:11:17Z
dc.date.available	2014-09-17T09:11:17Z
dc.date.issued	2014
dc.identifier.citation	Natural Product Research 28(18):1507-1512;2014	en_US
dc.identifier.issn	1478-6419
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/1662
dc.description.abstract	We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.	en_US
dc.language.iso	en	en_US
dc.publisher	Taylor & Francis	en_US
dc.subject	Cerbera odollam	en_US
dc.subject	Theviridoside	en_US
dc.subject	Theveside	en_US
dc.subject	Semi-synthetic derivatives	en_US
dc.title	Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam	en_US
dc.type	Article	en_US