Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells

dc.contributor.author	Jyothi B Nair
dc.contributor.author	Mohapatra, S
dc.contributor.author	Ghosh, S
dc.contributor.author	Maiti, K K
dc.date.accessioned	2015-02-20T04:44:49Z
dc.date.available	2015-02-20T04:44:49Z
dc.date.issued	2015
dc.identifier.citation	Chemical Communications 51(12):2403-6;27 Jan 2015	en_US
dc.identifier.issn	1364-548X
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/1784
dc.description.abstract	An efficient synthetic approach has been adopted to construct a new dendron-based octa-guanidine appended molecular transporter with a lysosomal targeted peptide-doxorubicin conjugate. The transporter alone (G8-PPI-FL) is found to be non-toxic, showed higher cellular uptake compared to Arg-8-mer and exhibited excellent selectivity towards lysosomes in cathepsin B expressing HeLa cells, while the Dox-conjugate showed significant cytotoxicity to cancer cells without affecting the non-cancerous cells.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Guanidinium-poly-(propylene imine)	en_US
dc.subject	Doxorubicin	en_US
dc.subject	Cancer cells	en_US
dc.subject	Lysosome	en_US
dc.title	Novel lysosome targeted molecular transporter built on a guanidinium-poly-(propylene imine) hybrid dendron for efficient delivery of doxorubicin into cancer cells	en_US
dc.type	Article	en_US