Browsing 2011 by Subject "Homodimer"

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Bharangin, a Diterpenoid Quinonemethide, abolishes constitutive and inducible nuclear factor-kappa B (NF-kappa B) activation by modifying p65 on Cysteine 38 residue and reducing inhibitor of nuclear factor-kappa B alpha Kinase activation, leading to suppression of NF-kappa B-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents

Gupta, S C; Kannappan, R; Kim, J; Rahman, G M; Francis, S K; Reshma, R; Mangalam S Nair; Das, J; Aggarwal, B B (American Society for Pharmacology and Experimental Therapeutics (ASPET), 2011)

Although inflammatory pathways have been linked with various chronic diseases including cancer, identification of an agent that can suppress these pathways has therapeutic potential. Herein we describe the identification ...

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