Synthesis of functionalized 3-spirocyclopropane-2-indolones from isomerised Baylis-Hillman adducts of isatin

Abstract

A facile, high yield stereoselective synthesis of functionalized diastereomeric 3 -spirocyclopropane-2-indolones (10-17a,b) from the isomerised bromo derivatives of Baylis-Hillman adducts of isatin(2-9a,b) by reductive cyclization with sodium borohydride is reported