N-heterocyclic carbene-catalyzed reaction of chalcones and enals via homoenolate: an efficient synthesis of 1,3,4-trisubstituted cyclopentenes

dc.contributor.author	Vijay Nair, G
dc.contributor.author	Sreekumar, V
dc.contributor.author	Manojkumar, P
dc.contributor.author	Suresh, E
dc.date.accessioned	2016-01-18T08:20:28Z
dc.date.available	2016-01-18T08:20:28Z
dc.date.issued	2006
dc.identifier.citation	Journal of the American Chemical Society 128(27):8736-8737;12 Jul 2006	en_US
dc.identifier.issn	0002-7863
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/2198
dc.description.abstract	Nucleophilic heterocyclic carbene-catalyzed cyclopentannulation of enals and chalcones via homoenolate has been observed for the first time. Serendipitously, the reaction lead to a very efficient synthesis of 3,4-trans-disubstituted-1-aryl cyclopentenes instead of the expected cyclopentanones. The strategy works well with thienylidene tetralone also, leading to the tricyclic cyclopentene derivative.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Bicyclic beta-lactones	en_US
dc.subject	Asymmetric-synthesis	en_US
dc.subject	Conjugate addition	en_US
dc.subject	Gamma butyrolactones	en_US
dc.subject	Alpha,beta-unsaturated aldehydes	en_US
dc.subject	Multicomponent reactions	en_US
dc.subject	Nucleophilic carbenes	en_US
dc.subject	Aldol lactonization	en_US
dc.subject	Direct annulations	en_US
dc.subject	Acetylenic esters	en_US
dc.title	N-heterocyclic carbene-catalyzed reaction of chalcones and enals via homoenolate: an efficient synthesis of 1,3,4-trisubstituted cyclopentenes	en_US
dc.type	Article	en_US