Abstract:
Cyclo(L-Pro- L-Asp) diketopiperazine was synthesized
and its antimicrobial properties were compared
against its 2-ketopiperazine analog. The results indicate the
significance of the peptide bond in antimicrobial property
of cyclo(L-Pro- L-Asp) against various pathogenic bacteria
and fungi with potent inhibitory effect over the 2-ketopiperazine
analog. Cyclo(L-Pro- L-Asp) exhibited a higher
inhibitory activity against Penicillium expansum (MIC
8 lg/mL) than the standard fungicide amphotericin B
(MIC 64 lg/mL). The most potent activity by cyclo(L-Pro-
L-Asp) was exhibited against Trichophyton rubrum (MIC
2 lg/mL).
