A comparative study of antimicrobial properties of cyclo(l-Pro- l-Asp) with its 2-ketopiperazine analog

dc.contributor.author	Challa, C
dc.contributor.author	Kumar, N
dc.contributor.author	Manju John
dc.contributor.author	Ravi S lankalaPalli
dc.date.accessioned	2016-02-02T09:40:16Z
dc.date.available	2016-02-02T09:40:16Z
dc.date.issued	2014-05
dc.identifier.citation	A comparative study of antimicrobial properties of cyclo(l-Pro- l-Asp) with its 2-ketopiperazine analog 23(5):2377-2385	en_US
dc.identifier.uri	http://ir.niist.res.in:8080/jspui/handle/123456789/2207
dc.description.abstract	Cyclo(L-Pro- L-Asp) diketopiperazine was synthesized and its antimicrobial properties were compared against its 2-ketopiperazine analog. The results indicate the significance of the peptide bond in antimicrobial property of cyclo(L-Pro- L-Asp) against various pathogenic bacteria and fungi with potent inhibitory effect over the 2-ketopiperazine analog. Cyclo(L-Pro- L-Asp) exhibited a higher inhibitory activity against Penicillium expansum (MIC 8 lg/mL) than the standard fungicide amphotericin B (MIC 64 lg/mL). The most potent activity by cyclo(L-Pro- L-Asp) was exhibited against Trichophyton rubrum (MIC 2 lg/mL).	en_US
dc.language.iso	en	en_US
dc.publisher	Springer	en_US
dc.subject	Diketopiperazines;2-Ketopiperazine;Minimum inhibitory concentration ;Disk diffusion assay; Antimicrobial activity	en_US
dc.title	A comparative study of antimicrobial properties of cyclo(l-Pro- l-Asp) with its 2-ketopiperazine analog	en_US
dc.type	Article	en_US