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Investigation of antifungal activity of stilbenes alone and in combination with fluconazole against candida albicans

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dc.contributor.author Nishant kumar, S
dc.contributor.author Jubi, Jacob
dc.contributor.author Nisha, G V
dc.contributor.author Asha, A
dc.contributor.author Dileep, C
dc.contributor.author Dileep kumar, BS
dc.date.accessioned 2016-02-10T11:14:01Z
dc.date.available 2016-02-10T11:14:01Z
dc.date.issued 2014-03
dc.identifier.citation International Journal of Pharmacy and Pharmaceutical Sciences 6(4):304-307 en_US
dc.identifier.uri http://ir.niist.res.in:8080/jspui/handle/123456789/2234
dc.description.abstract Objective: The objective of the present study was to evaluate the synergistic activity og two stilbenes in combination with fluconazole against candida albicans. Methods: In this study, we used two stilbenes [3,4',5-trihydroxystilbene (1) and 3,5-dihydroxy-4-isopropylstilbene (2)] purified from a bacterium associated with entomopathogenic nematode (EPN), to demonstrate both its intrinsic antifungal activity and its synergistic interaction with the fluconazole, in the treatment of C. albicans in vitro. The cytotoxicity of stilbenes was also tested against normal human cell line (FS normal fibroblast and L231 lung epithelial cell line). Results: Our results demonstrated that significant synergistic antifungal activity exists between the two stilbenes and fluconazole against C. albicans. The time kill assay also supports the synergistic activity. No cytotoxicity was recorded for stilbenes and stilbenes plus fluconazole up to 200 μg/mL. But fluconazole alone recorded significant cytotoxicity. Conclusion: These results suggest that stilbenes combined with antibiotics may be microbiologically beneficial. These findings have potential implications in delaying the development of resistance as the anticandidal effect is achieved with lower concentrations of both drugs. en_US
dc.language.iso en en_US
dc.publisher Innovare Academic Sciences en_US
dc.subject Anticandidal activity, Normal human cells, Stilbenes, Fluconazole en_US
dc.title Investigation of antifungal activity of stilbenes alone and in combination with fluconazole against candida albicans en_US
dc.type Article en_US


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