Abstract:
Zinc Sulphide (ZnS) nanoparticles, synthesised by sono-chemical route employing zinc
chloride and sodium sulphide, displayed significant anti-fungal property against the
pathogenic yeast Candida albicans (MTCC 227) at a minimum fungicidal concentration of
300 g/ml. The antifungal property of zinc sulphide particles is attributed to the generation of
reactive oxygen species due to the interaction of nanoparticles with water. Additionally, the
presence of Zn and S in the zone of inhibition area and the absence of antifungal effects for
large micron sized particles of ZnS suggests size induced effects leading to perturbation of
fungi cell membranes resulting in growth inhibition.
