Reactive Oxygen Species (ROS) Mediated Enhanced Anti-Candidal Activity of ZnS-ZnO Nano-composites with Low Inhibitory Concentrations

dc.contributor.author	Suyana, P
dc.contributor.author	Kumar, S N
dc.contributor.author	Nimisha, M
dc.contributor.author	Dileep Kumar, B S
dc.contributor.author	Nair, B N
dc.contributor.author	Peer Mohamed, A
dc.contributor.author	Warrier, K G K
dc.contributor.author	Hareesh, U S
dc.date.accessioned	2016-09-09T05:09:43Z
dc.date.available	2016-09-09T05:09:43Z
dc.date.issued	2015
dc.identifier.citation	RSC Advances, 5(94):76718-76728	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/2421
dc.description.abstract	Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS–ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.title	Reactive Oxygen Species (ROS) Mediated Enhanced Anti-Candidal Activity of ZnS-ZnO Nano-composites with Low Inhibitory Concentrations	en_US
dc.type	Article	en_US