In Vitro and in Vivo Demonstration of Photodynamic Activity and Cytoplasm Imaging through TPE Nanoparticles

dc.contributor.author	Jayaram, D T
dc.contributor.author	Ramos-Romero, S
dc.contributor.author	Shankar, B H
dc.contributor.author	Garrido, C
dc.contributor.author	Rubio, N
dc.contributor.author	Sanched-cid, L
dc.contributor.author	Gomez, S B
dc.contributor.author	Balanco, J
dc.contributor.author	Ramaiah, D
dc.date.accessioned	2016-10-27T06:42:16Z
dc.date.available	2016-10-27T06:42:16Z
dc.date.issued	2016
dc.identifier.citation	ACS chemical biololgy 11(1):104-112 2016	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/2485
dc.description.abstract	We synthesized novel tetraphenylethene (TPE) conjugates, which undergo unique self-assembly to form spherical nanoparticles that exhibited aggregation induced emission (AIE) in the near-infrared region. These nanoparticles showed significant singlet oxygen generation efficiency, negligible dark toxicity, rapid cellular uptake, efficient localization in cytoplasm, and high in vitro photocytotoxicity as well as in vivo photodynamic activity against a human prostate tumor animal model. This study demonstrates, for the first time, the power of the selfassembled AIE active tetraphenylethene conjugates in aqueous media as a nanoplatform for future therapeutic applications	en_US
dc.language.iso	en	en_US
dc.publisher	ACS Publication	en_US
dc.title	In Vitro and in Vivo Demonstration of Photodynamic Activity and Cytoplasm Imaging through TPE Nanoparticles	en_US
dc.type	Article	en_US