Desymmetrization of meso-Bicyclic Hydrazines: An Efficient Strategy Towards the Synthesis of Functionalized Cyclopentenes

Abstract

Desymmetrization of meso-bicyclic hydrazines offers a facile entry into the class of functionalized cyclopentenes. Various methodologies used along this direction are described in this account. Our attempts in this area proved that the palladium-catalyzed desymmetrization of these substrates with various organometallic reagents results in the formation of 3,4-disubstituted cyclopentenes.