Abstract:
One of the most important goals in contemporary synthetic organic chemistry is the development of
stereoselective carbon–carbon coupling reactions providing a broadly applicable method to synthesize
complex structures from simple precursors. Skeletal rearrangements of such simple precursors are
powerful processes for generating molecular diversity with atom economy. In this context, desymmetrization
of meso compounds provides an efficient route to asymmetric synthons of high value in a limited
number of steps