dc.contributor.author |
Debabrata, Dutta |
|
dc.contributor.author |
Susan, M. Alex |
|
dc.contributor.author |
Kondapa Naidu Bobba, Bobba |
|
dc.contributor.author |
Maiti, Kaustabh Kumar |
|
dc.contributor.author |
Sankarprasad, Bhuniya |
|
dc.date.accessioned |
2017-05-11T09:05:53Z |
|
dc.date.available |
2017-05-11T09:05:53Z |
|
dc.date.issued |
2016-11-18 |
|
dc.identifier.citation |
ACS Appl. Mater. Interfaces,8:33430−33438 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/123456789/2746 |
|
dc.description.abstract |
An optically modulated “turn-on” theranostic prodrug TP1 has
been explored and formulated with biotinylated poly(vinyl alcohol) (biotinPVA)
to obtain desired pharmacokinetics. TP1, consisting of the antineoplastic
camptothecin analogue SN-38, and the fluorescent dye rhodol green have been
covalently conjugated through a disulfide bond. Glutathione triggering the release
of drug and fluorophore has been well established by UV−vis measurements
through mass spectral analysis in physiological conditions. The biocompatible
biotinPVA formulated prodrug (PTP1) showed remarkably higher stability against
blood serum and cell-specific activation in contrast to that of TP1. Significantly,
PTP1 permits monitoring of the delivery and release of well-known topoisomerase
I inhibitor SN-38 by modulating fluorescence signal at λem 550 nm within
intracellular milieus. Moreover, theranostic probe PTP1 exhibited dose-dependent
antiproliferative activity against receptor-positive HeLa cells, whereas it did not
show such an effect against receptor-negative NIH3T3 cells. Finally, the cellspecific
antiproliferative activity of PTP1 via the apoptotic pathway is an efficient approach in cancer theranostics. Thus, futuristic
PTP1 could be a promising agent in which diagnostic and prognostic data will be monitored synergistically |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
ACS publication |
en_US |
dc.subject |
heranostic, |
en_US |
dc.subject |
poly(vinyl alcohol), |
en_US |
dc.subject |
biocompatible |
en_US |
dc.subject |
blood serum |
en_US |
dc.subject |
SN-38 |
en_US |
dc.subject |
antiproliferative |
en_US |
dc.title |
New Insight into a Cancer Theranostic Probe: Efficient Cell-Specific Delivery of SN-38 Guided by Biotinylated Poly(vinyl alcohol) |
en_US |
dc.type |
Article |
en_US |