Anticancer Activity Studies of Cubebin Isolated From Piper Cubeba and its Synthetic Derivatives

Dhanya, S R; Farha, A K; Arya, R M; Arun, K B; Remani, P; Nisha, P; Sunil, V; Mangalam, S N

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dc.contributor.author	Dhanya, S R
dc.contributor.author	Farha, A K
dc.contributor.author	Arya, R M
dc.contributor.author	Arun, K B
dc.contributor.author	Remani, P
dc.contributor.author	Nisha, P
dc.contributor.author	Sunil, V
dc.contributor.author	Mangalam, S N
dc.date.accessioned	2017-05-15T09:19:17Z
dc.date.available	2017-05-15T09:19:17Z
dc.date.issued	2016-04-01
dc.identifier.citation	Bioorganic & Medicinal Chemistry Letters, 26(7):1767-1771	en_US
dc.identifier.issn	0960-894X
dc.identifier.uri	http://hdl.handle.net/123456789/2766
dc.description.abstract	(−)-Cubebin, isolated from the seeds of Piper cubeba, and its five different types of derivatives (a total of 17), with varying functionalities, were tested for their in vitro anticancer activity against six human cancer cell lines (A549, K562, SiHa, KB, HCT116 and HT29) using MTT assay. Cubebin as well as its derivatives containing lactone and amide groups showed significant anticancer activity. In some of the tested cell lines, the amide derivatives showed higher activity. Morphological analysis indicated that these compounds act through apoptosis mediated pathway of cell death and we expect that these results will pave new paths in the development of novel anticancer agents by the derivatization of (−)-cubebin	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier	en_US
dc.subject	Cubebin	en_US
dc.subject	Hinokinin	en_US
dc.subject	Amide derivatives	en_US
dc.subject	Anticancer activity	en_US
dc.subject	Morphological analysis	en_US
dc.subject	Apoptosis	en_US
dc.title	Anticancer Activity Studies of Cubebin Isolated From Piper Cubeba and its Synthetic Derivatives	en_US
dc.type	Article	en_US