Sequential Ugi Reaction/Base-induced Ring Closing/IAAC Protocol Toward Triazolobenzodiazepine-fused Diketopiperazines and Hydantoins

dc.contributor.author	Robby, V
dc.contributor.author	Bamba, F
dc.contributor.author	Jonas, W
dc.contributor.author	Joice, T
dc.contributor.author	Jeroen, J
dc.contributor.author	Meervelt, L V
dc.contributor.author	Jubi John
dc.contributor.author	Wim, D
dc.date.accessioned	2018-06-01T10:54:36Z
dc.date.available	2018-06-01T10:54:36Z
dc.date.issued	2018-03-14
dc.identifier.citation	Beilstein Journal of Organic Chemistry, 14:626-633	en_US
dc.identifier.uri	http://10.10.100.66:8080/xmlui/handle/123456789/3090
dc.description.abstract	A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary functionalities for further transformations. The Ugi adducts were then subjected to a base-induced ring closing and an intramolecular azide–alkyne cycloaddition reaction in succession to obtain highly fused benzodiazepine frameworks.	en_US
dc.language.iso	en	en_US
dc.publisher	Beilstein-Institut	en_US
dc.subject	benzodiazepine	en_US
dc.subject	2,5-diketopiperazine	en_US
dc.subject	hydantoin	en_US
dc.subject	intramolecular	en_US
dc.subject	azide–alkyne cycloaddition	en_US
dc.subject	Ugi reaction	en_US
dc.title	Sequential Ugi Reaction/Base-induced Ring Closing/IAAC Protocol Toward Triazolobenzodiazepine-fused Diketopiperazines and Hydantoins	en_US
dc.type	Article	en_US