Synthesis and In Vitro Evaluation of Zerumbone Pendant Derivatives: Potent Candidates for Anti-Diabetic and Anti-Proliferative Activities

dc.contributor.author	Dhanya, B P
dc.contributor.author	Greeshma, G
dc.contributor.author	Reshmitha, T R
dc.contributor.author	Saranya, J
dc.contributor.author	Sharathna, P
dc.contributor.author	Shibi, I G
dc.contributor.author	Nisha, P
dc.contributor.author	Radhakrishnan, K V
dc.date.accessioned	2018-06-19T11:27:37Z
dc.date.available	2018-06-19T11:27:37Z
dc.date.issued	2017-05-26
dc.identifier.citation	New Journal of Chemistry, 41(15):6960-6964	en_US
dc.identifier.uri	http://10.10.100.66:8080/xmlui/handle/123456789/3111
dc.description.abstract	A series of zerumbone pendant derivatives were synthesized and evaluated for their a-glucosidase, a-amylase and glycation inhibition activities. In our study, some of the derivatives showed potent inhibitory activity in micromolar concentration. In addition, investigations were carried out to screen the cytotoxic effects of some selected derivatives against various cancer cell lines viz., A549, HCT116, HeLa, HT1080 and MDAMB231. Two of the derivatives showed potent activity towards HCT116 and HeLa cell lines.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.title	Synthesis and In Vitro Evaluation of Zerumbone Pendant Derivatives: Potent Candidates for Anti-Diabetic and Anti-Proliferative Activities	en_US
dc.type	Article	en_US