Abstract:
Objectives: Arsenic trioxide (As2O3) is a potent drug for acute promyelocytic leukaemia, but its clinical
trials are allied with some serious adverse events mainly cardiac functional abnormalities. So the
objective of our investigation is to identify the cardioprotective action of flaxseed oil (FSO), a
natural compound against As2O3 induced cardiotoxicity.
Methods: Male wistar rats were treated with As2O3 (4 mg/kg) to induce cardiotoxicity. FSO (250 and
500 mg/kg) was given in combination with As2O3 for evaluating its cardioprotective efficacy.
Results: Treatment with As2O3 resulted in deposition of arsenic in heart tissue, increased cardiac
marker enzymes release, lipid peroxidation (LPO), oxidative insults and pathological damages in the
heart. Co-treatment with FSO (500 mg/kg) significantly reduced the arsenic accumulation, cardiac
marker enzymes, LPO and cardiac structural alterations. FSO treatment significantly improved
cardiac glutathione content, antioxidant enzymes and reduced the pathological damages in cardiac
tissue. Gas chromatographic–mass spectrometry analysis revealed that the major fatty acid content
in the FSO is alpha-linolenic acid, which has a strong milieu in cardiac health.
Conclusion: The results of the current investigation suggested that FSO is an effective agent in
reducing arsenic-induced cardiac toxicity and can be used as an adjunct/dietary supplement for the
cancer patients on As2O3 therapy.
