Pd-Catalyzed Oxidative Annulation of Enamides with Diazabicyclic Olefins: Rapid Access to Cyclopentene Fused 2-Pyrrolines

Abstract

An efficient stereoselective route for the synthesis of cyclopentene fused 2-pyrrolines has been established via a Pd-catalyzed C–H activation/oxidative coupling of aryl enamides with diazabicyclic olefins. The proposed two-stage mechanismwas successfully proven by isolating the intermediate trans-disubstituted cyclopentene.