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Plasmonically Enhanced Galactoxyloglucan Endowed Gold Nanoparticles Exposed Tumor Targeting Biodistribution Envisaged in a Surface-Enhanced Raman Scattering Platform

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dc.contributor.author Joseph, M M
dc.contributor.author Nair, J B
dc.contributor.author Maiti, K K
dc.contributor.author Sreelekha, T T
dc.date.accessioned 2018-07-24T06:04:31Z
dc.date.available 2018-07-24T06:04:31Z
dc.date.issued 2017-11-15
dc.identifier.citation Biomacromolecules,18(12):4041-4053 en_US
dc.identifier.uri http://10.10.100.66:8080/xmlui/handle/123456789/3201
dc.description.abstract Biopolymer-capped gold nanoparticles (AuNPs) were perceived for tracing biodistribution in a solid tumor mice through surface-enhanced Raman scattering (SERS) fingerprinting. In this strategy, a robust and ecofriendly green chemistry approach was adopted to construct galactoxyloglucan (PST001) endowed AuNPs (PST-GNPs) with cancer-cell-selective toxic nature and excellent biocompatibility. Plasmonically enhanced lightscattering properties facilitated PST-GNPs to be a superior SERS substrate with high Raman signal enhancement. In this context, PST-GNPs were scrutinized for the noninvasive labelfree SERS live-cell spectral imaging to evaluate the fingerprint molecular details of cellular processes. Consequently, the inherent SERS feature of PST-GNPs enabled us to investigate the dynamic and complex nature with NP biodistrubution in tumor-bearing mice on a SERS platform that illustrated the tumor targeting nature. Henceforth, the present findings emphasized a futuristic clinically relevant scenario for tracing the in vivo NP dissemination in a label-free fashion for providing vital biochemical details on a molecular level. en_US
dc.language.iso en en_US
dc.publisher American Chemical Society en_US
dc.title Plasmonically Enhanced Galactoxyloglucan Endowed Gold Nanoparticles Exposed Tumor Targeting Biodistribution Envisaged in a Surface-Enhanced Raman Scattering Platform en_US
dc.type Article en_US


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