dc.contributor.author |
Joseph, M M |
|
dc.contributor.author |
Nair, J B |
|
dc.contributor.author |
Maiti, K K |
|
dc.contributor.author |
Sreelekha, T T |
|
dc.date.accessioned |
2018-07-24T06:04:31Z |
|
dc.date.available |
2018-07-24T06:04:31Z |
|
dc.date.issued |
2017-11-15 |
|
dc.identifier.citation |
Biomacromolecules,18(12):4041-4053 |
en_US |
dc.identifier.uri |
http://10.10.100.66:8080/xmlui/handle/123456789/3201 |
|
dc.description.abstract |
Biopolymer-capped gold nanoparticles (AuNPs) were perceived for tracing biodistribution in a solid tumor mice through surface-enhanced Raman scattering (SERS) fingerprinting. In this strategy, a robust and ecofriendly green chemistry approach was adopted to construct galactoxyloglucan (PST001) endowed AuNPs (PST-GNPs) with cancer-cell-selective toxic nature and excellent biocompatibility. Plasmonically enhanced lightscattering properties facilitated PST-GNPs to be a superior SERS substrate with high Raman signal enhancement. In this context, PST-GNPs were scrutinized for the noninvasive labelfree SERS live-cell spectral imaging to evaluate the fingerprint molecular details of cellular processes. Consequently, the inherent SERS feature of PST-GNPs enabled us to investigate the dynamic and complex nature with NP biodistrubution in
tumor-bearing mice on a SERS platform that illustrated the tumor targeting nature. Henceforth, the present findings emphasized a futuristic clinically relevant scenario for tracing the in vivo NP dissemination in a label-free fashion for providing vital biochemical details on a molecular level. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
American Chemical Society |
en_US |
dc.title |
Plasmonically Enhanced Galactoxyloglucan Endowed Gold Nanoparticles Exposed Tumor Targeting Biodistribution Envisaged in a Surface-Enhanced Raman Scattering Platform |
en_US |
dc.type |
Article |
en_US |