Abstract:
The anisotropic features of Au nanorods make them an attractive nanoscale precursor for the design of higher order nanostructured materials. However, the mode of interaction of various molecular systems on Au nanorods is not well-understood. In the present study, we have employed isothermal titration calorimetry and surface-enhanced Raman scattering for understanding various types of interactions of functional molecules on
the surface of gold nanorods. The binding of thiol-bearing analyte molecules is effective with the surface of gold
nanorods in acetonitrile-rich solvents and found to be weak in an aqueous medium. The effective interaction
of thiol-bearing analyte molecules on nanorods is facilitated by the breakdown of cetyltrimethylammonium
bromide bilayer to a monolayer in organic-rich solvent systems, thereby resulting in appreciable signals in
isothermal titration calorimetry and surface-enhanced Raman spectra. The electrostatic interaction of analyte
molecule is mainly driven by the charge reversal on the surface of Au nanorods on switching the solvent
from aqueous to organic medium. Thus, based on isothermal titration calorimetry and surface-enhanced Raman scattering investigations, it is established that the microheterogeneous environment around the Au nanorods plays a crucial role in driving the interaction of analyte molecules.
