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Nucleophile‐Initiated Catalytic and Multicomponent Reactions

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dc.contributor.author Nair, V
dc.contributor.author Menon, R S
dc.date.accessioned 2019-06-28T10:47:32Z
dc.date.available 2019-06-28T10:47:32Z
dc.date.issued 2019-02
dc.identifier.citation The Chemical Record; 19(2-3):347–361 en_US
dc.identifier.uri https://onlinelibrary.wiley.com/doi/abs/10.1002/tcr.201800027
dc.description.abstract A number of well‐known reactions, proceed through the intermediacy of dipolar/zwitterionic species generated via the addition of a neutral nucleophile with an unsaturated electrophile. A mechanistic understanding of these reactions was made possible by seminal contributions of Huisgen. The design of novel reactions based on such dipolar species was, however, not pursued in detail for a long time. Our efforts to exploit various reactivity profiles available for the zwitterionic/dipolar intermediates have resulted in the discovery of a large number of novel, convenient protocols to access a wide variety of products. The nucleophilic initiators may participate in the reaction or play a mediating role depending upon the nature of nucleophile, its quantity and the reaction conditions. In a majority of these transformations two electrophilic components, that would normally be inert towards each other, are combined by the intermediacy of a nucelophile. A brief summary of such nucleophile‐initiated novel reactions that were developed in our research group are described. Reactions involving a variety of nucleophiles such as phosphines, pyridine, quinoline, isoquinoline, isocyanides, dimethoxycarbene and N‐heterocyclic carbenes (NHCs) are discussed. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Multicomponent reactions en_US
dc.subject Organocatalysis en_US
dc.subject Zwitterions and Homoenolate en_US
dc.title Nucleophile‐Initiated Catalytic and Multicomponent Reactions en_US
dc.type Article en_US

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    Research articles authored by NIIST researchers published in 2019

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